Adam P. Siebert, Ph.D.

Affiliations: 
2012 Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
General Biophysics, Physiology Biology
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"Adam Siebert"

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James K. Foskett grad student 2012 Penn
 (Convergent structural and functional evolution of CALHM ion channel with connexins and pannexins-innexins.)
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Lee RJ, Kofonow JM, Rosen PL, et al. (2014) Bitter and sweet taste receptors regulate human upper respiratory innate immunity. The Journal of Clinical Investigation. 124: 1393-405
Siebert AP, Ma Z, Grevet JD, et al. (2013) Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins. The Journal of Biological Chemistry. 288: 6140-53
Kopil CM, Siebert AP, Foskett JK, et al. (2012) Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons. Journal of Neurochemistry. 123: 147-58
Ma Z, Siebert AP, Cheung KH, et al. (2012) Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability. Proceedings of the National Academy of Sciences of the United States of America. 109: E1963-71
Kopil CM, Vais H, Cheung KH, et al. (2011) Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis. The Journal of Biological Chemistry. 286: 35998-6010
Vais H, Siebert AP, Ma Z, et al. (2010) Redox-regulated heterogeneous thresholds for ligand recruitment among InsP3R Ca2+-release channels. Biophysical Journal. 99: 407-16
Dreses-Werringloer U, Lambert JC, Vingtdeux V, et al. (2008) A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. Cell. 133: 1149-61
Parkington JD, LeBrasseur NK, Siebert AP, et al. (2004) Contraction-mediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscle. Journal of Applied Physiology (Bethesda, Md. : 1985). 97: 243-8
Parkington JD, Siebert AP, LeBrasseur NK, et al. (2003) Differential activation of mTOR signaling by contractile activity in skeletal muscle. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 285: R1086-90
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