Rafael J. Rojas, Ph.D.
Affiliations: | 2007 | Pharmacology | University of North Carolina, Chapel Hill, Chapel Hill, NC |
Area:
BiochemistryGoogle:
"Rafael Rojas"Parents
Sign in to add mentor| John E. Sondek | grad student | 2007 | UNC Chapel Hill | |
| (Coordinating the activation of RhoA by diverse RhoGEFs: SmgGDS and G -alpha -q -responsive Dbl family guanine nucleotide exchange factors.) | ||||
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Publications
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| Hamel B, Monaghan-Benson E, Rojas RJ, et al. (2011) SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC. The Journal of Biological Chemistry. 286: 12141-8 |
| Evelyn CR, Ferng T, Rojas RJ, et al. (2009) High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay. Journal of Biomolecular Screening. 14: 161-72 |
| Rojas RJ, Yohe ME, Gershburg S, et al. (2007) Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain. The Journal of Biological Chemistry. 282: 29201-10 |
| Pruitt K, Ulkü AS, Frantz K, et al. (2005) Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. The Journal of Biological Chemistry. 280: 23363-70 |
| Rojas RJ, Kimple RJ, Rossman KL, et al. (2003) Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases. Combinatorial Chemistry & High Throughput Screening. 6: 409-18 |
| Rossman KL, Cheng L, Mahon GM, et al. (2003) Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. The Journal of Biological Chemistry. 278: 18393-400 |