Isaac S. Chan, Ph.D.
Affiliations: | 2012 | Genetics & Molecular Biology | University of North Carolina, Chapel Hill, Chapel Hill, NC |
Area:
Genetics, Molecular Biology, OncologyGoogle:
"Isaac Chan"Parents
Sign in to add mentor| Anna M. Diehl | grad student | 2012 | UNC Chapel Hill | |
| (Hedgehog signaling in hepatocellular carinoma.) | ||||
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Publications
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| Pereira TA, Syn WK, MacHado MV, et al. (2015) Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni. Clinical Science (London, England : 1979) |
| Chan IS, Guy CD, Machado MV, et al. (2014) Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis. Alcoholism, Clinical and Experimental Research. 38: 787-800 |
| Pereira TA, Xie G, Choi SS, et al. (2013) Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. Liver International : Official Journal of the International Association For the Study of the Liver. 33: 149-61 |
| Xie G, Choi SS, Syn WK, et al. (2013) Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation. Gut. 62: 299-309 |
| Chan IS, Guy CD, Chen Y, et al. (2012) Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma. Cancer Research. 72: 6344-50 |
| Chen Y, Choi SS, Michelotti GA, et al. (2012) Hedgehog controls hepatic stellate cell fate by regulating metabolism. Gastroenterology. 143: 1319-29.e1-11 |
| Syn WK, Agboola KM, Swiderska M, et al. (2012) NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease. Gut. 61: 1323-9 |
| Chan IS, Swiderska M, Guy CD, et al. (2012) Su1587 Hedgehog Inhibition Regulates the Stromal Microenvironment in Hepatocellular Carcinoma via Suppression of the Warburg Effect Gastroenterology. 142: S-972 |
| Philips GM, Chan IS, Swiderska M, et al. (2011) Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. Plos One. 6: e23943 |