Christopher R. Vakoc, Ph.D.

Affiliations: 
2008- Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
Area:
Molecular Biology
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"Christopher Vakoc"

Parents

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Gerd A. Blobel grad student 2006 Penn
 (Histone lysine methylation and chromatin loop formation associated with transcription activation.)
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Publications

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Lan X, Khandros E, Huang P, et al. (2019) The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells. Blood Advances. 3: 1586-1597
Bharathy N, Berlow NE, Wang E, et al. (2019) Preclinical rationale for entinostat in embryonal rhabdomyosarcoma. Skeletal Muscle. 9: 12
Bharathy N, Berlow NE, Wang E, et al. (2018) The HDAC3-SMARCA4-miR-27a axis promotes expression of the fusion oncogene in rhabdomyosarcoma. Science Signaling. 11
Skucha A, Ebner J, Schmöllerl J, et al. (2018) MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nature Communications. 9: 1983
Hohmann AF, Martin LJ, Minder JL, et al. (2016) Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition. Nature Chemical Biology
Bhagwat AS, Roe JS, Mok BY, et al. (2016) BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements. Cell Reports
Martin LJ, Koegl M, Bader G, et al. (2016) Structure-based design of an in vivo active selective BRD9 inhibitor. Journal of Medicinal Chemistry
Bhagwat AS, Vakoc CR. (2015) Targeting Transcription Factors in Cancer. Trends in Cancer. 1: 53-65
Shen C, Ipsaro JJ, Shi J, et al. (2015) NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. Molecular Cell
Matthews GM, Mehdipour P, Cluse LA, et al. (2015) Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies. Blood
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