Aaron Patrick, Ph.D.
Affiliations: | 2009 | University of Colorado Anschutz Medical Campus, Denver, Aurora, CO |
Area:
Molecular BiologyGoogle:
"Aaron Patrick"Parents
Sign in to add mentor| Heide L. Ford | grad student | 2009 | University of Colorado, Denver | |
| (Structure-function analysis of the Six1/Eya transcriptional complex.) | ||||
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Publications
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| Blevins MA, Towers CG, Patrick AN, et al. (2015) The SIX1-EYA transcriptional complex as a therapeutic target in cancer. Expert Opinion On Therapeutic Targets. 19: 213-25 |
| Krueger AB, Drasin DJ, Lea WA, et al. (2014) Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. The Journal of Biological Chemistry. 289: 16349-61 |
| Kohrt D, Crary J, Zimmer M, et al. (2014) CDK6 binds and promotes the degradation of the EYA2 protein. Cell Cycle (Georgetown, Tex.). 13: 62-71 |
| Patrick AN, Cabrera JH, Smith AL, et al. (2013) Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome. Nature Structural & Molecular Biology. 20: 447-53 |
| Patrick A, Blevins M, Krueger A, et al. (2013) Abstract B102: Targeting the SIX1/EYA transcriptional complex as a potential anti-cancer therapy. Molecular Cancer Therapeutics. 12 |
| Wang CA, Jedlicka P, Patrick AN, et al. (2012) SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer. The Journal of Clinical Investigation. 122: 1895-906 |
| Qamar L, Deitsch E, Patrick AN, et al. (2012) Specificity and prognostic validation of a polyclonal antibody to detect Six1 homeoprotein in ovarian cancer. Gynecologic Oncology. 125: 451-7 |
| Ford H, Patrick A, Varella-Garcia M. (2011) SIX1 (sine oculis homeobox homolog 1) (mammalian) Atlas of Genetics and Cytogenetics in Oncology and Haematology |
| Patrick A, Cabrera J, Zhao R, et al. (2011) Abstract C127: Crystal structure of the SIX1/EYA transcriptional complex reveals ways to inhibit SIX1-mediated breast tumorigenesis/metastasis. Molecular Cancer Therapeutics. 10 |
| Patrick AN, Schiemann BJ, Yang K, et al. (2009) Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations. The Journal of Biological Chemistry. 284: 20781-90 |