Zhong-Yin Zhang

Biochemistry and Molecular Biology Indiana University, Bloomington, Bloomington, IN, United States 
Biochemistry, Analytical Chemistry, Molecular Biology
"Zhong-Yin Zhang"


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Jinpeng Sun grad student 2001-2006 (Neurotree)
Chad D. Walls grad student 2012 Indiana University
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Gebregiworgis T, Kano Y, St-Germain J, et al. (2021) The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors. Nature Communications. 12: 6274
Krabill AD, Zhang ZY. (2021) Functional interrogation and therapeutic targeting of protein tyrosine phosphatases. Biochemical Society Transactions. 49: 1723-1734
Xu YF, Chen X, Yang Z, et al. (2021) PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. Embo Reports. e52141
Chen H, Libring S, Ruddraraju KV, et al. (2020) SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer. Oncogene
Zhu G, Xie J, Kong W, et al. (2020) Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation. Cell
Li Q, Bai Y, Lyle LT, et al. (2020) Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America
Ruddraraju KV, Aggarwal D, Niu C, et al. (2020) Highly Potent and Selective N-aryl Oxamic Acid Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (mPTPB). Journal of Medicinal Chemistry
Zhang RY, Yu ZH, Chen L, et al. (2020) Mechanistic insights explain the transforming potential of the T507K substitution in the protein tyrosine phosphatase SHP2. The Journal of Biological Chemistry
Li Y, Gardner JJ, Fortney KR, et al. (2019) First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors. Bioorganic & Medicinal Chemistry Letters
Kano Y, Gebregiworgis T, Marshall CB, et al. (2019) Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation. Nature Communications. 10: 224
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