Brett D. Hollingshead, Ph.D.

2006 Pennsylvania State University, State College, PA, United States 
Molecular Biology, Toxicology
"Brett Hollingshead"


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Gary H. Perdew grad student 2006 Penn State
 (In vitro and in vivo analysis of aryl hydrocarbon receptor regulation by the hepatitis B virus X -associated protein 2.)
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Butler P, Lawton M, Chapin RE, et al. (2016) CHAPTER 12: Safety considerations for epigenetic mechanisms as drug targets: Are existing toxicology studies fit for purpose? Rsc Drug Discovery Series. 2016: 288-315
Labrecque MP, Takhar MK, Hollingshead BD, et al. (2012) Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines. Plos One. 7: e29545
Perdew GH, Hollingshead BD, Dinatale BC, et al. (2010) Estrogen receptor expression is required for low-dose resveratrol-mediated repression of aryl hydrocarbon receptor activity. The Journal of Pharmacology and Experimental Therapeutics. 335: 273-83
Beischlag TV, Luis Morales J, Hollingshead BD, et al. (2008) The aryl hydrocarbon receptor complex and the control of gene expression. Critical Reviews in Eukaryotic Gene Expression. 18: 207-50
Hollingshead BD, Beischlag TV, Dinatale BC, et al. (2008) Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells. Cancer Research. 68: 3609-17
Patel RD, Hollingshead BD, Omiecinski CJ, et al. (2007) Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver. Hepatology (Baltimore, Md.). 46: 209-18
Hollingshead BD, Patel RD, Perdew GH. (2006) Endogenous hepatic expression of the hepatitis B virus X-associated protein 2 is adequate for maximal association with aryl hydrocarbon receptor-90-kDa heat shock protein complexes. Molecular Pharmacology. 70: 2096-107
Hollingshead BD, Petrulis JR, Perdew GH. (2004) The aryl hydrocarbon (Ah) receptor transcriptional regulator hepatitis B virus X-associated protein 2 antagonizes p23 binding to Ah receptor-Hsp90 complexes and is dispensable for receptor function. The Journal of Biological Chemistry. 279: 45652-61
Ramadoss P, Petrulis JR, Hollingshead BD, et al. (2004) Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes. Biochemistry. 43: 700-9
Petrulis JR, Kusnadi A, Ramadoss P, et al. (2003) The hsp90 Co-chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah receptor and represses transcriptional activity. The Journal of Biological Chemistry. 278: 2677-85
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