Colin A. Flaveny, Ph.D.

Affiliations: 
2010 Pennsylvania State University, State College, PA, United States 
Area:
Molecular Biology, Toxicology
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"Colin Flaveny"

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Gary H. Perdew grad student 2010 Penn State
 (Molecular and species-specific determinants of aryl hydrocarbon receptor transcriptional activity.)
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Publications

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Schaub FX, Reza MS, Flaveny CA, et al. (2015) Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis. Cancer Research
Griffett K, Welch RD, Flaveny CA, et al. (2015) The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis. Molecular Metabolism. 4: 353-7
Li B, Flaveny CA, Giambelli C, et al. (2014) Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis. Plos One. 9: e101969
Li B, Fei DL, Flaveny CA, et al. (2014) Pyrvinium attenuates Hedgehog signaling downstream of smoothened. Cancer Research. 74: 4811-21
Flaveny CA, Solt LA, Kojetin DJ, et al. (2014) Biased Signaling and Conformational Dynamics in Nuclear Hormone Receptors Biased Signaling in Physiology, Pharmacology and Therapeutics. 103-135
Fei DL, Sanchez-Mejias A, Wang Z, et al. (2012) Hedgehog signaling regulates bladder cancer growth and tumorigenicity. Cancer Research. 72: 4449-58
Murray IA, Flaveny CA, Chiaro CR, et al. (2011) Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Molecular Pharmacology. 79: 508-19
Boitano AE, Wang J, Romeo R, et al. (2010) Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science (New York, N.Y.). 329: 1345-8
Murray IA, Krishnegowda G, DiNatale BC, et al. (2010) Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chemical Research in Toxicology. 23: 955-66
DiNatale BC, Murray IA, Schroeder JC, et al. (2010) Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 89-97
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