Brett C. DiNatale, Ph.D.

2013 Pennsylvania State University, State College, PA, United States 
Molecular Biology
"Brett DiNatale"


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Gary H. Perdew grad student 2013 Penn State
 (The role of the aryl hydrocarbon receptor in tumor cell phenotype.)
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DiNatale BC, Smith K, John K, et al. (2012) Ah receptor antagonism represses head and neck tumor cell aggressive phenotype. Molecular Cancer Research : McR. 10: 1369-79
DiNatale BC, Schroeder JC, Perdew GH. (2011) Ah receptor antagonism inhibits constitutive and cytokine inducible IL6 production in head and neck tumor cell lines. Molecular Carcinogenesis. 50: 173-83
Perdew GH, Hollingshead BD, Dinatale BC, et al. (2010) Estrogen receptor expression is required for low-dose resveratrol-mediated repression of aryl hydrocarbon receptor activity. The Journal of Pharmacology and Experimental Therapeutics. 335: 273-83
DiNatale BC, Schroeder JC, Francey LJ, et al. (2010) Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling. The Journal of Biological Chemistry. 285: 24388-97
Murray IA, Krishnegowda G, DiNatale BC, et al. (2010) Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chemical Research in Toxicology. 23: 955-66
DiNatale BC, Perdew GH. (2010) Protein function analysis: rapid, cell-based siRNA-mediated ablation of endogenous expression with simultaneous ectopic replacement. Cytotechnology. 62: 495-503
DiNatale BC, Murray IA, Schroeder JC, et al. (2010) Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 89-97
Schroeder JC, Dinatale BC, Murray IA, et al. (2010) The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor. Biochemistry. 49: 393-400
Murray IA, Morales JL, Flaveny CA, et al. (2010) Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity. Molecular Pharmacology. 77: 247-54
Murray IA, Flaveny CA, DiNatale BC, et al. (2010) Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone. The Journal of Pharmacology and Experimental Therapeutics. 332: 135-44
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