Raúl Padrón
Affiliations: | 1966-1979 | Centro de Biología Estructural | Instituto Venezolano de Investigaciones Cientificas, Parroquia Macarao, Miranda, Venezuela |
1980-1983 | Structural Studies Division | MRC Laboratory of Molecular Biology, Cambridge, England, United Kingdom | |
1983- | Centro de Biología Estructural | Instituto Venezolano de Investigaciones Cientificas, Parroquia Macarao, Miranda, Venezuela |
Area:
Muscle structure and functionWebsite:
http://www.raul-padron.org/lab/Google:
"Raul Padron IVIC"Bio:
Raúl Padrón is emeritus investigator, Center of Structural Biology, Venezuelan Institute for Scientific Research (IVIC), Caracas. After his postdoctoral work at the MRC Laboratory of Molecular Biology (Cambridge, UK), he founded the Dept. of Structural Biology of IVIC in 1997, where he was an international research scholar of the Howard Hughes Medical Institute until 2011. He has devoted his career to the study of the structure and function of thick filaments from striated and smooth muscle. His contributions include the elucidation of the atomic structure of thick filaments from striated muscle and the proposal of a molecular mechanism for its activation. His honors include: Polar Prize (1991); CONICIT Biology Prizes (1989, 1990, 1996); FONACIT Biology Prize (2005); and the National Prize in Science and Technology of Venezuela (2008). He is a member of the Latin-American Acad. of Sciences.
Parents
Sign in to add mentorKarl August Gaede Jaekel | research assistant | 1966-1971 | Instituto Venezolano de Investigaciones Cientificas | |
(Visiting Student August 1966, Assistant Student 1966-1971) | ||||
Jorge Villegas | research assistant | 1971-1972 | Instituto Venezolano de Investigaciones Cientificas | |
(Assistant Student 1971-1972) | ||||
John G. Nicholls | research assistant | 1972-1972 | Instituto Venezolano de Investigaciones Cientificas (Neurotree) | |
(One month assistant student) | ||||
Carlo Caputo | grad student | 1972-1975 | Instituto Venezolano de Investigaciones Cientificas | |
(Electrical Engineering Thesis) | ||||
Leonardo Mateu | grad student | 1975-1979 | Instituto Venezolano de Investigaciones Cientificas | |
(M. Sc. and Ph. D. Thesis in Biology (Physiology and Biophysics)) | ||||
Aaron Klug | post-doc | 1980-1980 | MRC-LMB (Chemistry Tree) | |
(Postdoctoral fellow September-October 1980) | ||||
Hugh Esmor Huxley | post-doc | 1980-1983 | MRC-LMB (Chemistry Tree) | |
(Postdoctoral fellow October 1980 - March 1983) |
Children
Sign in to add traineeCollaborators
Sign in to add collaboratorRoger Craig | collaborator | 1980- | University of Massachusetts Medical Center, Worcester |
Lorenzo Alamo | collaborator | 1986- | Instituto Venezolano de Investigaciones Cientificas |
Antonio Pinto | collaborator | 1998- | Instituto Venezolano de Investigaciones Cientificas |
Willy Wriggers | collaborator | 2006- |
Publications
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Dutta D, Nguyen V, Campbell KS, et al. (2023) Cryo-EM structure of the human cardiac myosin filament. Nature |
Dutta D, Nguyen V, Campbell KS, et al. (2023) Cryo-EM structure of the human cardiac myosin filament. Biorxiv : the Preprint Server For Biology |
Padrón R, Dutta D, Craig R. (2022) Variants of the myosin interacting-heads motif. The Journal of General Physiology. 155 |
Koubassova NA, Tsaturyan AK, Bershitsky SY, et al. (2022) Interacting-Heads Motif Explains the X-Ray Diffraction Pattern of Relaxed Vertebrate Skeletal Muscle. Biophysical Journal |
Craig R, Padrón R. (2021) Structural basis of the super- and hyper-relaxed states of myosin II. The Journal of General Physiology. 154 |
Ma W, Duno-Miranda S, Irving T, et al. (2021) Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms. The Journal of General Physiology. 153 |
Yang S, Tiwari P, Lee KH, et al. (2020) Cryo-EM structure of the inhibited (10S) form of myosin II. Nature |
Padrón R, Ma W, Duno-Miranda S, et al. (2020) The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms. Proceedings of the National Academy of Sciences of the United States of America |
Sulbarán G, Biasutto A, Méndez F, et al. (2020) O labeling on Ser45 but not on Ser35 supports the cooperative phosphorylation mechanism on tarantula thick filament activation. Biochemical and Biophysical Research Communications |
Toepfer CN, Garfinkel AC, Venturini G, et al. (2020) Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy. Circulation |