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Raúl Padrón

Affiliations: 
1966-1979 Centro de Biología Estructural Instituto Venezolano de Investigaciones Cientificas, Parroquia Macarao, Miranda, Venezuela 
 1980-1983 Structural Studies Division MRC Laboratory of Molecular Biology, Cambridge, England, United Kingdom 
 1983- Centro de Biología Estructural Instituto Venezolano de Investigaciones Cientificas, Parroquia Macarao, Miranda, Venezuela 
Area:
Muscle structure and function
Website:
http://www.raul-padron.org/lab/
Google:
"Raul Padron IVIC"
Bio:

Raúl Padrón is emeritus investigator, Center of Structural Biology, Venezuelan Institute for Scientific Research (IVIC), Caracas. After his postdoctoral work at the MRC Laboratory of Molecular Biology (Cambridge, UK), he founded the Dept. of Structural Biology of IVIC in 1997, where he was an international research scholar of the Howard Hughes Medical Institute until 2011. He has devoted his career to the study of the structure and function of thick filaments from striated and smooth muscle. His contributions include the elucidation of the atomic structure of thick filaments from striated muscle and the proposal of a molecular mechanism for its activation. His honors include: Polar Prize (1991); CONICIT Biology Prizes (1989, 1990, 1996); FONACIT Biology Prize (2005); and the National Prize in Science and Technology of Venezuela (2008). He is a member of the Latin-American Acad. of Sciences.

Parents

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Karl August Gaede Jaekel research assistant 1966-1971 Instituto Venezolano de Investigaciones Cientificas
 (Visiting Student August 1966, Assistant Student 1966-1971)
Jorge Villegas research assistant 1971-1972 Instituto Venezolano de Investigaciones Cientificas
 (Assistant Student 1971-1972)
John G. Nicholls research assistant 1972-1972 Instituto Venezolano de Investigaciones Cientificas (Neurotree)
 (One month assistant student)
Carlo Caputo grad student 1972-1975 Instituto Venezolano de Investigaciones Cientificas
 (Electrical Engineering Thesis)
Leonardo Mateu grad student 1975-1979 Instituto Venezolano de Investigaciones Cientificas
 (M. Sc. and Ph. D. Thesis in Biology (Physiology and Biophysics))
Aaron Klug post-doc 1980-1980 MRC-LMB (Chemistry Tree)
 (Postdoctoral fellow September-October 1980)
Hugh Esmor Huxley post-doc 1980-1983 MRC-LMB (Chemistry Tree)
 (Postdoctoral fellow October 1980 - March 1983)
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Publications

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Padrón R, Ma W, Duno-Miranda S, et al. (2020) The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms. Proceedings of the National Academy of Sciences of the United States of America
Sulbarán G, Biasutto A, Méndez F, et al. (2020) O labeling on Ser45 but not on Ser35 supports the cooperative phosphorylation mechanism on tarantula thick filament activation. Biochemical and Biophysical Research Communications
Toepfer CN, Garfinkel AC, Venturini G, et al. (2020) Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy. Circulation
Alamo L, Koubassova N, Pinto A, et al. (2017) Lessons from a tarantula: new insights into muscle thick filament and myosin interacting-heads motif structure and function. Biophysical Reviews
Alamo L, Pinto A, Sulbarán G, et al. (2017) Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease. Biophysical Reviews
Alamo L, Ware JS, Pinto A, et al. (2017) Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes. Elife. 6
Alamo L, Qi D, Wriggers W, et al. (2016) Conserved intramolecular interactions maintain myosin interacting-heads motifs explaining tarantula muscle super-relaxed state structural basis. Journal of Molecular Biology
Sulbarán G, Alamo L, Pinto A, et al. (2015) An invertebrate smooth muscle with striated muscle myosin filaments. Proceedings of the National Academy of Sciences of the United States of America. 112: E5660-8
Alamo L, Li XE, Espinoza-Fonseca LM, et al. (2015) Tarantula myosin free head regulatory light chain phosphorylation stiffens N-terminal extension, releasing it and blocking its docking back. Molecular Biosystems. 11: 2180-9
Espinoza-Fonseca LM, Alamo L, Pinto A, et al. (2015) Sequential myosin phosphorylation activates tarantula thick filament via a disorder-order transition. Molecular Biosystems. 11: 2167-79
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