Alexander Varshavsky
Affiliations: | Biology and Biological Engineering | California Institute of Technology, Pasadena, CA |
Area:
Protein degradation, ubiquitinWebsite:
https://www.bbe.caltech.edu/people/alexander-varshavskyGoogle:
"Alexander Varshavsky"Bio:
http://www.nasonline.org/member-directory/members/67746.html
Cross-listing: Neurotree - Chemistry Tree
Children
Sign in to add traineeDaniel Finley | grad student | Caltech | |
Mark Solomon | grad student | 1986 | MIT |
Bonnie Bartel | grad student | 1990 | MIT (Chemistry Tree) |
Anna Shemorry | grad student | 2013 | Caltech (Neurotree) |
Brandon Wadas | grad student | 2008-2016 | Caltech |
Michael Ellison | post-doc | MIT | |
Stefan Jentsch | post-doc | MIT | |
Mark W. Hochstrasser | post-doc | 1990 | MIT |
Jixi Li | post-doc | 2006-2008 | Caltech (Chemistry Tree) |
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Publications
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Kim BH, Kim MK, Oh SJ, et al. (2022) Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates. Proceedings of the National Academy of Sciences of the United States of America. 119: e2209597119 |
Chen SJ, Kim L, Song HK, et al. (2021) Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathway. Proceedings of the National Academy of Sciences of the United States of America. 118 |
Vu TTM, Mitchell DC, Gygi SP, et al. (2020) The Arg/N-degron pathway targets transcription factors and regulates specific genes. Proceedings of the National Academy of Sciences of the United States of America |
Vu TTM, Varshavsky A. (2020) The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway. Biochemistry |
Dong C, Chen SJ, Melnykov A, et al. (2020) Recognition of nonproline N-terminal residues by the Pro/N-degron pathway. Proceedings of the National Academy of Sciences of the United States of America |
Oh JH, Hyun JY, Chen SJ, et al. (2020) Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling. Proceedings of the National Academy of Sciences of the United States of America |
Chen SJ, Melnykov A, Varshavsky A. (2020) Evolution of Substrates and Components of the Pro/N-Degron Pathway. Biochemistry |
Melnykov A, Chen SJ, Varshavsky A. (2019) Gid10 as an alternative N-recognin of the Pro/N-degron pathway. Proceedings of the National Academy of Sciences of the United States of America |
Varshavsky A. (2019) On the cause of sleep: Protein fragments, the concept of sentinels, and links to epilepsy. Proceedings of the National Academy of Sciences of the United States of America |
Varshavsky A. (2019) N-degron and C-degron pathways of protein degradation. Proceedings of the National Academy of Sciences of the United States of America. 116: 358-366 |