Tania A. Baker

Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
macromolecular machines
"Tania A. Baker"


Cross-listing: Chemistry Tree


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Arthur Kornberg grad student 1988 Stanford
 (Early events during initiation of DNA replication from the E. coli chromosomal origin)
Kiyoshi Mizuuchi post-doc NIH


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Briana Burton grad student MIT
Hema Chandra Kotamarthi post-doc 2014-2020 MIT (Chemistry Tree)
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Sauer RT, Fei X, Bell TA, et al. (2021) Structure and function of ClpXP, a AAA+ proteolytic machine powered by probabilistic ATP hydrolysis. Critical Reviews in Biochemistry and Molecular Biology. 1-17
Zuromski KL, Kim S, Sauer RT, et al. (2021) Division of labor between the pore-1 loops of the D1 and D2 AAA+ rings coordinates substrate selectivity of the ClpAP protease. The Journal of Biological Chemistry. 101407
Baytshtok V, Fei X, Shih TT, et al. (2021) Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug. Cell Reports. 34: 108639
Kim S, Zuromski KL, Bell TA, et al. (2020) ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP. Elife. 9
Mawla GD, Hall BM, Cárcamo-Oyarce G, et al. (2020) ClpP1P2 peptidase activity promotes biofilm formation in P. aeruginosa. Molecular Microbiology
Saunders RA, Stinson BM, Baker TA, et al. (2020) Multistep substrate binding and engagement by the AAA+ ClpXP protease. Proceedings of the National Academy of Sciences of the United States of America
Fei X, Bell TA, Barkow SR, et al. (2020) Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates. Elife. 9
Zuromski KL, Sauer RT, Baker TA. (2020) Modular and coordinated activity of AAA+ active sites in the double-ring ClpA unfoldase of the ClpAP protease. Proceedings of the National Academy of Sciences of the United States of America
Torres-Delgado A, Kotamarthi HC, Sauer RT, et al. (2020) The intrinsically disordered N-terminal extension of the ClpS adaptor reprograms its partner AAA+ ClpAP protease. Journal of Molecular Biology
Fei X, Bell TA, Jenni S, et al. (2020) Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife. 9
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