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Leland H. Hartwell

Fred Hutchinson Cancer Research Center, Seattle, WA, United States 
Cell Cycle
"Leland Hartwell"
Hartwell, Leland H, Studies on the induction of histidase in Bacillus subtilis, thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1964
Discovered cell cycle deffective (cdc) mutants in budding yeast.
The Nobel Prize in Physiology or Medicine 2001 was awarded jointly to Leland H. Hartwell, Tim Hunt and Sir Paul M. Nurse for their discoveries of key regulators of the cell cycle.


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Boris Magasanik grad student 1964 MIT
 (Studies on the induction of histidase in Bacillus subtilis)
Renato Dulbecco post-doc 1965 Salk Institute


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Mandy Paulovich grad student Fred Hutchinson Cancer Center (Neurotree)
D. Ry Wagner grad student University of Washington (Evolution Tree)
Susan K. Dutcher grad student 1975-1980 University of Washington (Computer Science Tree)
Kathrin Schrick grad student 1994 University of Washington (Chemistry Tree)
Tim Formosa post-doc University of Washington (Chemistry Tree)
Eric Foss post-doc Fred Hutchinson Cancer Center (Neurotree)
John Pringle post-doc Fred Hutchinson Cancer Center
Steve Reed post-doc (PombeTree)
Douglas Elliott Koshland post-doc 1982-1986 University of Washington
Peter Pryciak post-doc 1991-1996 UMass Worchester (Neurotree)
David Toczyski post-doc 1998 (Chemistry Tree)
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Hartwell LH. (2004) Yeast and cancer. Bioscience Reports. 24: 523-44
Hartwell LH. (2002) Nobel Lecture. Yeast and cancer. Bioscience Reports. 22: 373-94
Emili A, Schieltz DM, Yates JR, et al. (2001) Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1. Molecular Cell. 7: 13-20
Nurse P, Masui Y, Hartwell L. (1998) Understanding the cell cycle Nature Medicine. 4: 1103-1106
Paulovich AG, Armour CD, Hartwell LH. (1998) The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage. Genetics. 150: 75-93
Toczyski DP, Galgoczy DJ, Hartwell LH. (1997) CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell. 90: 1097-106
Schrick K, Garvik B, Hartwell LH. (1997) Mating in Saccharomyces cerevisiae: the role of the pheromone signal transduction pathway in the chemotropic response to pheromone. Genetics. 147: 19-32
Dorer R, Boone C, Kimbrough T, et al. (1997) Genetic analysis of default mating behavior in Saccharomyces cerevisiae. Genetics. 146: 39-55
Paulovich AG, Toczyski DP, Hartwell LH. (1997) When checkpoints fail. Cell. 88: 315-21
Pryciak PM, Hartwell LH. (1996) AKR1 encodes a candidate effector of the G beta gamma complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction. Molecular and Cellular Biology. 16: 2614-26
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