Leland H. Hartwell
Affiliations: | Fred Hutchinson Cancer Research Center, Seattle, WA, United States |
Area:
Cell CycleWebsite:
http://www.fhcrc.org/content/public/en/labs/profiles/hartwell-lee.htmlGoogle:
"Leland Hartwell"Bio:
http://www.nobelprize.org/nobel_prizes/medicine/laureates/2001/hartwell-cv.html
http://www.nasonline.org/member-directory/members/15538.html
Hartwell, Leland H, Studies on the induction of histidase in Bacillus subtilis, thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1964
Discovered cell cycle deffective (cdc) mutants in budding yeast.
The Nobel Prize in Physiology or Medicine 2001 was awarded jointly to Leland H. Hartwell, Tim Hunt and Sir Paul M. Nurse for their discoveries of key regulators of the cell cycle
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Photo
Parents
Sign in to add mentor| Boris Magasanik | grad student | 1964 | MIT | |
| (Studies on the induction of histidase in Bacillus subtilis) | ||||
| Renato Dulbecco | post-doc | 1965 | Salk Institute | |
Children
Sign in to add trainee| Mandy Paulovich | grad student | Fred Hutchinson Cancer Center (Neurotree) | |
| D. Ry Wagner | grad student | University of Washington (Evolution Tree) | |
| Susan K. Dutcher | grad student | 1975-1980 | University of Washington (Computer Science Tree) |
| Kathrin Schrick | grad student | 1994 | University of Washington (Chemistry Tree) |
| Tim Formosa | post-doc | University of Washington (Chemistry Tree) | |
| Eric Foss | post-doc | Fred Hutchinson Cancer Center (Neurotree) | |
| John Pringle | post-doc | Fred Hutchinson Cancer Center | |
| Steve Reed | post-doc | (PombeTree) | |
| Douglas Elliott Koshland | post-doc | 1982-1986 | University of Washington |
| Peter Pryciak | post-doc | 1991-1996 | UMass Worchester (Neurotree) |
| David Toczyski | post-doc | 1998 | (Chemistry Tree) |
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Publications
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| Hartwell LH. (2004) Yeast and cancer. Bioscience Reports. 24: 523-44 |
| Hartwell LH. (2002) Nobel Lecture. Yeast and cancer. Bioscience Reports. 22: 373-94 |
| Emili A, Schieltz DM, Yates JR, et al. (2001) Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1. Molecular Cell. 7: 13-20 |
| Nurse P, Masui Y, Hartwell L. (1998) Understanding the cell cycle Nature Medicine. 4: 1103-1106 |
| Paulovich AG, Armour CD, Hartwell LH. (1998) The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage. Genetics. 150: 75-93 |
| Toczyski DP, Galgoczy DJ, Hartwell LH. (1997) CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell. 90: 1097-106 |
| Schrick K, Garvik B, Hartwell LH. (1997) Mating in Saccharomyces cerevisiae: the role of the pheromone signal transduction pathway in the chemotropic response to pheromone. Genetics. 147: 19-32 |
| Dorer R, Boone C, Kimbrough T, et al. (1997) Genetic analysis of default mating behavior in Saccharomyces cerevisiae. Genetics. 146: 39-55 |
| Paulovich AG, Toczyski DP, Hartwell LH. (1997) When checkpoints fail. Cell. 88: 315-21 |
| Pryciak PM, Hartwell LH. (1996) AKR1 encodes a candidate effector of the G beta gamma complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction. Molecular and Cellular Biology. 16: 2614-26 |