Aaron Shatkin

Affiliations: 
Rutgers University, New Brunswick, New Brunswick, NJ, United States 
Area:
Molecular Biology
Website:
http://www.nasonline.org/member-directory/deceased-members/50565.html
Google:
"Aaron J. Shatkin"
Bio:

(1934 - 2012)
http://dx.doi.org/10.1073/pnas.1215048109
http://dx.doi.org/10.1126/science.1226820

Discovered the 5'cap, which is present at the beginning of eukaryotic mRNAs.

Cross-listing: Chemistry Tree - DevTree

Parents

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Edward Tatum grad student Rockefeller (Chemistry Tree)
Norman Salzman post-doc NIH (Chemistry Tree)
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Publications

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Topisirovic I, Svitkin YV, Sonenberg N, et al. (2011) Cap and cap-binding proteins in the control of gene expression. Wiley Interdisciplinary Reviews. Rna. 2: 277-98
Shatkin A, Das K, Arnold E. (2008) 3D jigsaw puzzle in rotavirus assembly. Structure (London, England : 1993). 16: 1601-2
Chu C, Shatkin AJ. (2008) Apoptosis and autophagy induction in mammalian cells by small interfering RNA knockdown of mRNA capping enzymes. Molecular and Cellular Biology. 28: 5829-36
Srinivasan P, Piano F, Shatkin AJ. (2003) mRNA capping enzyme requirement for Caenorhabditis elegans viability. The Journal of Biological Chemistry. 278: 14168-73
Wen Y, Shatkin AJ. (2000) Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha. Genes & Development. 14: 2944-9
Furuichi Y, Shatkin AJ. (2000) Viral and cellular mRNA capping: past and prospects. Advances in Virus Research. 55: 135-84
Pillutla RC, Shimamoto A, Furuichi Y, et al. (1999) Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. Genomics. 56: 217-20
Pillutla RC, Shimamoto A, Furuichi Y, et al. (1998) Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively. Genomics. 54: 351-3
Wen Y, Yue Z, Shatkin AJ. (1998) Mammalian capping enzyme binds RNA and uses protein tyrosine phosphatase mechanism. Proceedings of the National Academy of Sciences of the United States of America. 95: 12226-31
Pillutla RC, Yue Z, Maldonado E, et al. (1998) Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. The Journal of Biological Chemistry. 273: 21443-6
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