Jeffrey A. Bluestone

Affiliations: 
University of Chicago, Chicago, IL 
Area:
Cell Biology, Immunology, Molecular Biology
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"Jeffrey Bluestone"

Parents

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David Sachs grad student

Children

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Maria-Luisa Alegre grad student Chicago
Ingrid C. Rulifson grad student 2000 Chicago
Keshava Rajagopal grad student 2001 Chicago
Cristina Penaranda grad student 2005-2010 UCSF (Microtree)
Anne I Sperling post-doc (Neurotree)
Leonardo M.R. Ferreira post-doc 2016- UCSF
Daniel Bryan Goodman post-doc 2017- UCSF (Chemistry Tree)
Brian T. Fife post-doc 2002-2007 UCSF (Microtree)
Todd M. Brusko post-doc 2008-2011 (Epi Tree)
Gaurav Chopra post-doc 2013-2016 UCSF (Computational Biology Tree)

Collaborators

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Eugene P Brandon collaborator (Neurotree)
Yapeng Su collaborator (Chemistry Tree)
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Publications

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Lebrec H, Bui J, Clingan JM, et al. (2025) Second generation CD2-targeting LFA-3 fusion protein SBT115301 to restore immune homeostasis in autoimmune disease. Iscience. 28: 112447
Stoops J, Morton T, Powell J, et al. (2025) Treg cell therapy manufacturability: current state of the art, challenges and new opportunities. Frontiers in Immunology. 16: 1604483
Bluestone JA, Burnett BK, Crute CE, et al. (2025) Regulatory T cell therapies to treat autoimmune diseases and transplant rejection. Nature Immunology. 26: 819-824
Muller YD, Ho P, Bluestone JA, et al. (2024) Rebalancing the Immune System to Treat Type 1 Diabetes. Cold Spring Harbor Perspectives in Medicine
Smith JA, Yuen BTK, Purtha W, et al. (2024) Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones. Proceedings of the National Academy of Sciences of the United States of America. 121: e2320268121
Ho P, Cahir-McFarland E, Fontenot JD, et al. (2024) Harnessing regulatory T cells to establish immune tolerance. Science Translational Medicine. 16: eadm8859
Bluestone JA, McKenzie BS, Beilke J, et al. (2023) Opportunities for Treg cell therapy for the treatment of human disease. Frontiers in Immunology. 14: 1166135
Goodman DB, Azimi CS, Kearns K, et al. (2022) Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies. Science Translational Medicine. 14: eabm1463
VanDyke D, Iglesias M, Tomala J, et al. (2022) Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection. Cell Reports. 41: 111478
Su Y, Yuan D, Chen DG, et al. (2022) Multiple early factors anticipate post-acute COVID-19 sequelae. Cell
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