Geoffrey W. Krystal

Affiliations: 
Virginia Commonwealth University, Richmond, VA, United States 
Area:
Molecular Biology, Cell Biology, Oncology
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"Geoffrey Krystal"
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Publications

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Xu H, Krystal GW. (2010) Actinomycin D decreases Mcl-1 expression and acts synergistically with ABT-737 against small cell lung cancer cell lines. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 4392-400
Hauck P, Chao BH, Litz J, et al. (2009) Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737. Molecular Cancer Therapeutics. 8: 883-92
Rodina A, Vilenchik M, Moulick K, et al. (2007) Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nature Chemical Biology. 3: 498-507
Litz J, Krystal GW. (2006) Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells. Molecular Cancer Therapeutics. 5: 1415-22
Krystal GW. (2005) Receptor tyrosine kinase mutations: molecular indicators for therapeutic response or signposts marking important signaling pathways? Cancer Biology & Therapy. 4: 1417-8
Warshamana-Greene GS, Litz J, Buchdunger E, et al. (2005) The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 1563-71
Litz J, Sakuntala Warshamana-Greene G, Sulanke G, et al. (2004) The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth and angiogenesis, in part by blocking Kit-mediated VEGF expression. Lung Cancer (Amsterdam, Netherlands). 46: 283-91
Warshamana-Greene GS, Litz J, Buchdunger E, et al. (2004) The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Molecular Cancer Therapeutics. 3: 527-35
Krystal GW. (2004) Imatinib mesylate (STI571) for myeloid malignancies other than CML. Leukemia Research. 28: S53-9
Yu C, Subler M, Rahmani M, et al. (2003) Induction of apoptosis in BCR/ABL+ cells by histone deacetylase inhibitors involves reciprocal effects on the RAF/MEK/ERK and JNK pathways. Cancer Biology & Therapy. 2: 544-51
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