Leona D. Samson

Harvard University, Cambridge, MA, United States 
Genetics, Molecular Biology, Cell Biology
"Leona Samson"



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John Forster Cairns grad student 1978 University of London
 (Studies on mutagenesis in Escherichia coli.)


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Mark John Hickman grad student 2003 Harvard
Dragony Fu post-doc MIT (Telomere and Telomerase Tree)
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Montaldo NP, Bordin DL, Brambilla A, et al. (2019) Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression. Nature Communications. 10: 5460
Chaim IA, Nagel ZD, Jordan JJ, et al. (2017) In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities. Proceedings of the National Academy of Sciences of the United States of America
Allocca M, Corrigan JJ, Fake KR, et al. (2017) PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration. Oncotarget. 8: 68707-68720
Jordan JJ, Chhim S, Margulies CM, et al. (2017) ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage. Cell Death & Disease. 8: e2947
Calvo JA, Allocca M, Fake KR, et al. (2016) Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner. Oncotarget
Yu AM, Calvo JA, Muthupalani S, et al. (2016) The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury. Oncotarget
Fu D, Samson LD, Hübscher U, et al. (2015) The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants. Dna Repair. 35: 13-18
McFaline-Figueroa JL, Braun CJ, Stanciu M, et al. (2015) Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide. Cancer Research
Ebrahimkhani MR, Daneshmand A, Mazumder A, et al. (2014) Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney. Proceedings of the National Academy of Sciences of the United States of America. 111: E4878-86
Kiraly O, Gong G, Roytman MD, et al. (2014) DNA glycosylase activity and cell proliferation are key factors in modulating homologous recombination in vivo. Carcinogenesis. 35: 2495-502
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