Christin L. Hanigan, Ph.D.
Affiliations: | 2008 | Johns Hopkins University, Baltimore, MD |
Area:
Oncology, Molecular BiologyGoogle:
"Christin Hanigan"Parents
Sign in to add mentorRobert A. Casero | grad student | 2008 | Johns Hopkins | |
(Identification of a truncating mutation in HDAC2 and its role in regulating apoptotic response to HDACi.) |
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Publications
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Almaliti J, Al-Hamashi AA, Negmeldin AT, et al. (2016) Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue. Journal of Medicinal Chemistry |
Bhansali P, Hanigan CL, Perera L, et al. (2014) Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups. European Journal of Medicinal Chemistry. 86: 528-41 |
Murray-Stewart T, Hanigan CL, Woster PM, et al. (2013) Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism Molecular Cancer Therapeutics. 12: 2088-2099 |
Jin L, Hanigan CL, Wu Y, et al. (2013) Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1 (DNA methyltransferase 1)-independent manner Biochemical Journal. 449: 459-468 |
Yun J, Johnson JL, Hanigan CL, et al. (2012) Interactions between epigenetics and metabolism in cancers. Frontiers in Oncology. 2: 163 |
Bhansali P, Hanigan CL, Casero RA, et al. (2011) Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation. Journal of Medicinal Chemistry. 54: 7453-63 |
Hanigan CL, Van Engeland M, De Bruine AP, et al. (2008) An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1. Gastroenterology. 135: 1654-1664.e2 |
Futscher BW, Oshiro MM, Wozniak RJ, et al. (2002) Role for DNA methylation in the control of cell type specific maspin expression. Nature Genetics. 31: 175-9 |