Doris R. Brown, Ph.D.

Affiliations: 
2000 Wake Forest University School of Medicine, Winston-Salem, NC, United States 
Area:
Molecular Biology, Oncology
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"Doris Brown"

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Swati P. Deb grad student 2000 Wake Forest School of Medicine
 (Function and dysfunction of human oncoprotein MDM2.)
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Publications

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Brown DR, Deb D, Frum R, et al. (2001) The human oncoprotein MDM2 uses distinct strategies to inhibit transcriptional activation mediated by the wild-type p53 and its tumor-derived mutants. International Journal of Oncology. 18: 449-59
Deb D, Lanyi A, Scian M, et al. (2001) Differential modulation of cellular and viral promoters by p73 and p53. International Journal of Oncology. 18: 401-9
Brown DR, Thomas CA, Deb SP. (1998) The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis. The Embo Journal. 17: 2513-25
Ludes-Meyers JH, Subler MA, Shivakumar CV, et al. (1996) Transcriptional activation of the human epidermal growth factor receptor promoter by human p53. Molecular and Cellular Biology. 16: 6009-19
Shivakumar CV, Brown DR, Deb S, et al. (1995) Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter Molecular and Cellular Biology. 15: 6785-6793
Leng P, Brown DR, Shivakumar CV, et al. (1995) N-terminal 130 amino acids of MDM2 are sufficient to inhibit p53-mediated transcriptional activation. Oncogene. 10: 1275-82
Deb SP, Muñoz RM, Brown DR, et al. (1994) Wild-type human p53 activates the human epidermal growth factor receptor promoter. Oncogene. 9: 1341-9
Deb SP, Deb S, Brown DS. (1994) Cell-type-specific induction of the UL9 gene of HSV-1 by cell signaling pathway Biochemical and Biophysical Research Communications. 205: 44-51
Brown DR, Deb S, Muñoz RM, et al. (1993) The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein. Molecular and Cellular Biology. 13: 6849-57
Martin DW, Subler MA, Muñoz RM, et al. (1993) p53 and SV40 T antigen bind to the same region overlapping the conserved domain of the TATA-binding protein. Biochemical and Biophysical Research Communications. 195: 428-34
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