Chonghui Cheng, Ph.D.

Affiliations: 
2000 Weill Cornell Medical College, New York, NY, United States 
Area:
Molecular Biology
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"Chonghui Cheng"

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Stuart Shuman grad student 2000 Weill Cornell Medical College
 (Structural and functional analysis of vaccinia virus DNA topoisomerase.)
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Publications

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Cheng C, Shuman S. (2000) Recombinogenic flap ligation pathway for intrinsic repair of topoisomerase IB-induced double-strand breaks. Molecular and Cellular Biology. 20: 8059-68
Woodfield G, Cheng C, Shuman S, et al. (2000) Vaccinia topoisomerase and Cre recombinase catalyze direct ligation of activated DNA substrates containing a 3'-para-nitrophenyl phosphate ester. Nucleic Acids Research. 28: 3323-31
Sekiguchi J, Cheng C, Shuman S. (2000) Resolution of a Holliday junction by vaccinia topoisomerase requires a spacer DNA segment 3' of the CCCTT/ cleavage sites. Nucleic Acids Research. 28: 2658-63
Klemm M, Cheng C, Cassell G, et al. (2000) Peptide inhibitors of DNA cleavage by tyrosine recombinases and topoisomerases Journal of Molecular Biology. 299: 1203-1216
Cheng C, Shuman S. (2000) DNA strand transfer catalyzed by vaccinia topoisomerase: ligation of DNAs containing a 3' mononucleotide overhang. Nucleic Acids Research. 28: 1893-8
Cheng C, Shuman S. (1999) Site-specific DNA transesterification by vaccinia topoisomerase: role of specific phosphates and nucleosides. Biochemistry. 38: 16599-612
Krogh BO, Cheng C, Burgin A, et al. (1999) Melanoplus sanguinipes entomopoxvirus DNA topoisomerase: site-specific DNA transesterification and effects of 5'-bridging phosphorothiolates. Virology. 264: 441-51
Cheng C, Shuman S. (1998) A catalytic domain of eukaryotic DNA topoisomerase I. The Journal of Biological Chemistry. 273: 11589-95
Cheng C, Kussie P, Pavletich N, et al. (1998) Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases Cell. 92: 841-850
Sekiguchi J, Cheng C, Shuman S. (1997) Kinetic analysis of DNA and RNA strand transfer reactions catalyzed by vaccinia topoisomerase. The Journal of Biological Chemistry. 272: 15721-8
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