Mercedes E. Gorre, Ph.D.

2003 University of California, Los Angeles, Los Angeles, CA 
Molecular Biology, Oncology, Pharmacology
"Mercedes Gorre"


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Charles Sawyers grad student 2003 UCLA
 (Molecular mechanisms of STI571 resistance and disease progression in chronic myelogenous leukemia.)
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Leder K, Foo J, Skaggs B, et al. (2011) Fitness conferred by BCR-ABL kinase domain mutations determines the risk of pre-existing resistance in chronic myeloid leukemia. Plos One. 6: e27682
Dawson AJ, Bal S, McTavish B, et al. (2011) Inversion and deletion of 16q22 defined by array CGH, FISH, and RT-PCR in a patient with AML. Cancer Genetics. 204: 344-7
Skaggs BJ, Gorre ME, Ryvkin A, et al. (2006) Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants. Proceedings of the National Academy of Sciences of the United States of America. 103: 19466-71
Huron DR, Gorre ME, Kraker AJ, et al. (2003) A novel pyridopyrimidine inhibitor of abl kinase is a picomolar inhibitor of Bcr-abl-driven K562 cells and is effective against STI571-resistant Bcr-abl mutants. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 1267-73
Gorre ME, Ellwood-Yen K, Chiosis G, et al. (2002) BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. Blood. 100: 3041-4
Shah NP, Nicoll JM, Nagar B, et al. (2002) Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2: 117-25
Roumiantsev S, Shah NP, Gorre ME, et al. (2002) Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop. Proceedings of the National Academy of Sciences of the United States of America. 99: 10700-5
Gorre ME, Sawyers CL. (2002) Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia. Current Opinion in Hematology. 9: 303-7
Gorre ME, Mohammed M, Ellwood K, et al. (2001) Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science (New York, N.Y.). 293: 876-80
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