Kedar Hastak, Ph.D.
Affiliations: | 2003 | Case Western Reserve University School of Medicine, Cleveland, OH, United States |
Area:
Molecular Biology, Cell BiologyGoogle:
"Kedar Hastak"Parents
Sign in to add mentor| Hasan Mukhtar | grad student | 2003 | Case Western Medical School | |
| (Molecular pathways of apoptosis induced by green tea polyphenol epigallocatechin -3 -gallate.) | ||||
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Publications
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| Hastak K, Bhutra S, Parry R, et al. (2017) Poly (ADP-ribose) polymerase inhibitor, an effective radiosensitizer in lung and pancreatic cancers. Oncotarget |
| Hastak K, McPherson L, Shen Y, et al. (2014) Abstract 5490: Poly (ADP-ribose) polymerase inhibitor LT-626 sensitizes lung and pancreatic cancers to fractionated radiation therapy Cancer Research. 74: 5490-5490 |
| Hastak K, Adimoolam S, Trinklein ND, et al. (2012) Identification of a Functional In Vivo p53 Response Element in the Coding Sequence of the Xeroderma Pigmentosum Group C Gene. Genes & Cancer. 3: 131-40 |
| Hastak K, Alli E, Ford JM. (2010) Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-ribose) polymerase inhibition, gemcitabine, and cisplatin Cancer Research. 70: 7970-7980 |
| Thakur VS, Ruhul Amin AR, Paul RK, et al. (2010) p53-Dependent p21-mediated growth arrest pre-empts and protects HCT116 cells from PUMA-mediated apoptosis induced by EGCG. Cancer Letters. 296: 225-32 |
| Hastak K, Paul RK, Agarwal MK, et al. (2008) DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation. Proceedings of the National Academy of Sciences of the United States of America. 105: 6314-9 |
| Agarwal MK, Hastak K, Jackson MW, et al. (2006) Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors. Proceedings of the National Academy of Sciences of the United States of America. 103: 16278-83 |
| Hastak K, Agarwal MK, Mukhtar H, et al. (2005) Ablation of either p21 or Bax prevents p53-dependent apoptosis induced by green tea polyphenol epigallocatechin-3-gallate. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 789-91 |
| Gupta S, Hastak K, Afaq F, et al. (2004) Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis. Oncogene. 23: 2507-22 |
| Hastak K, Gupta S, Ahmad N, et al. (2003) Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells. Oncogene. 22: 4851-9 |