David N. Ciccone, Ph.D.

Affiliations: 
2007 Harvard University, Cambridge, MA, United States 
Area:
Immunology, Molecular Biology
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"David Ciccone"

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Marjorie Oettinger grad student 2007 Harvard
 (The epigenetic regulation of V(D)J recombination: Chromatin architecture and the insulator protein, CTCF.)
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Publications

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Ciccone DN, Namiki Y, Chen C, et al. (2019) The murine IgH locus contains a distinct DNA sequence motif for the chromatin regulatory factor CTCF. The Journal of Biological Chemistry
Martin FJ, Xu Y, Lohmann F, et al. (2015) KMT1E-mediated chromatin modifications at the FcγRIIb promoter regulate thymocyte development. Genes and Immunity. 16: 162-9
Balter BB, Ciccone DN, Oettinger MA, et al. (2012) Mice lacking Sμ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations. Molecular Immunology. 52: 1-8
Ciccone DN, Su H, Hevi S, et al. (2009) KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature. 461: 415-8
Ciccone DN, Chen T. (2009) Histone lysine methylation in genomic imprinting. Epigenetics. 4: 216-20
Matthews AG, Kuo AJ, Ramón-Maiques S, et al. (2007) RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. 450: 1106-10
Ciccone D, Oettinger M. (2004) Chromatin modifications as clues to the regulation of antigen receptor assembly. Novartis Foundation Symposium. 259: 146-58; discussion 1
Ciccone DN, Morshead KB, Oettinger MA. (2004) Chromatin immunoprecipitation in the analysis of large chromatin domains across murine antigen receptor loci. Methods in Enzymology. 376: 334-48
Morshead KB, Ciccone DN, Taverna SD, et al. (2003) Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proceedings of the National Academy of Sciences of the United States of America. 100: 11577-82
Ng HH, Ciccone DN, Morshead KB, et al. (2003) Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proceedings of the National Academy of Sciences of the United States of America. 100: 1820-5
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