Xian M. O'Brien, Ph.D.

2010 Brown University, Providence, RI 
Cell Biology
"Xian O'Brien"


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Jonathan Reichner grad student 2010 Brown
 (Innate immune functions of human polymorphonuclear leukocytes as mediated by the beta2 integrin, CR3, and modulated by beta-glucan, a fungal pathogen associated molecular pattern.)
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Dickinson CM, LeBlanc BW, Edhi MM, et al. (2018) Leukadherin-1 ameliorates endothelial barrier damage mediated by neutrophils from critically ill patients. Journal of Intensive Care. 6: 19
Johnson CM, O'Brien XM, Byrd AS, et al. (2016) Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal β-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response. Journal of Immunology (Baltimore, Md. : 1950)
O'Brien XM, Biron BM, Reichner JS. (2016) Consequences of extracellular trap formation in sepsis. Current Opinion in Hematology
O'Brien XM, Reichner JS. (2016) Neutrophil Integrins and Matrix Ligands and NET Release. Frontiers in Immunology. 7: 363
Biron BM, Chung CS, O'Brien XM, et al. (2016) Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model. Journal of Innate Immunity
Byrd AS, O'Brien XM, Laforce-Nesbitt SS, et al. (2015) NETosis in Neonates: Evidence of a Reactive Oxygen Species-Independent Pathway in Response to Fungal Challenge. The Journal of Infectious Diseases
Loosley AJ, O'Brien XM, Reichner JS, et al. (2015) Describing directional cell migration with a characteristic directionality time. Plos One. 10: e0127425
O'Brien XM, Loosley AJ, Oakley KE, et al. (2014) Technical advance: introducing a novel metric, directionality time, to quantify human neutrophil chemotaxis as a function of matrix composition and stiffness. Journal of Leukocyte Biology. 95: 993-1004
Loosley AJ, O'Brien XM, Reichner JS, et al. (2014) Quantification of Directional Migration by a Characteristic Directionality Time Biophysical Journal. 106: 573a
Byrd AS, O'Brien XM, Johnson CM, et al. (2013) An extracellular matrix-based mechanism of rapid neutrophil extracellular trap formation in response to Candida albicans. Journal of Immunology (Baltimore, Md. : 1950). 190: 4136-48
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