Rafal Swiercz, Ph.D.

Affiliations: 
2001 Medical College of Ohio, Toledo, OH, United States 
Area:
Molecular Biology
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"Rafal Swiercz"

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Jerzy Jankun grad student 2001 Medical College of Ohio
 (Evaluation of 14-1B mutant of recombinant human plasminogen activator inhibitor type 1 (PAI-1) as a potential anti-angiogenic and anti-cancer agent.)
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Publications

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Kantara C, Sarkar S, Swiercz R, et al. (2011) Abstract 4363: Inhibitory efficacy of curcumin ± stem cell specific RNAi on the growth of tumorospheres in vitro: Assay development and mechanisms of action Cancer Research. 71: 4363-4363
Kantara C, Sarkar S, Swiercz R, et al. (2011) Overexpression of Progastrin Imparts Tumorigenic/Metastatic Potential to Immortalized Embryonic Cells and Cancer Cells: Role of Stem/Progenitor Cell Markers and AnnexinA2 Gastroenterology. 140: S-48
Chorostowska-Wynimko J, Swiercz R, Skrzypczak-Jankun E, et al. (2005) P-022 Plasminogen activator inhibitor type-1 regulates the lungcapilaries endothelial cells (HMVEC-L) angiogenic activity via urokinase-dependent pathway Lung Cancer. 49: S121
Chorostowska-Wynimko J, Swiercz R, Skrzypczak-Jankun E, et al. (2004) Plasminogen activator inhibitor type-1 mutants regulate angiogenesis of human umbilical and lung vascular endothelial cells. Oncology Reports. 12: 1155-62
Chorostowska-Wynimko J, Swiercz R, Skrzypczak-Jankun E, et al. (2003) A novel form of the plasminogen activator inhibitor created by cysteine mutations extends its half-life: relevance to cancer and angiogenesis. Molecular Cancer Therapeutics. 2: 19-28
Swiercz R, Keck RW, Skrzypczak-Jankun E, et al. (2001) Recombinant PAI-1 inhibits angiogenesis and reduces size of LNCaP prostate cancer xenografts in SCID mice. Oncology Reports. 8: 463-70
Swiercz R, Skrzypczak-Jankun E, Merrell MM, et al. (1999) Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator. Oncology Reports. 6: 523-6
Swiercz R, Wolfe JD, Zaher A, et al. (1998) Expression of the plasminogen activation system in kidney cancer correlates with its aggressive phenotype Clinical Cancer Research. 4: 869-877
Jankun J, Selman SH, Swiercz R, et al. (1997) Why drinking green tea could prevent cancer. Nature. 387: 561
Jankun J, Keck RW, Skrzypczak-Jankun E, et al. (1997) Inhibitors of urokinase reduce size of prostate cancer xenografts in severe combined immunodeficient mice. Cancer Research. 57: 559-63
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