Agnieszka J. Szczepek, Ph.D.

Affiliations: 
2000 University of Alberta, Edmonton, Alberta, Canada 
Area:
Oncology, Cell Biology
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"Agnieszka Szczepek"

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Linda Pilarski grad student 2000 University of Alberta
 (Detection and characterization of circulating clonal cells in human multiple myeloma.)
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Publications

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Treon SP, Pilarski LM, Belch AR, et al. (2002) CD20-directed serotherapy in patients with multiple myeloma: biologic considerations and therapeutic applications. Journal of Immunotherapy (Hagerstown, Md. : 1997). 25: 72-81
Reiman T, Seeberger K, Taylor BJ, et al. (2001) Persistent preswitch clonotypic myeloma cells correlate with decreased survival: evidence for isotype switching within the myeloma clone. Blood. 98: 2791-9
Szczepek AJ, Belch AR, Pilarski LM. (2001) Expression of IL-6 and IL-6 receptors by circulating clonotypic B cells in multiple myeloma: potential for autocrine and paracrine networks. Experimental Hematology. 29: 1076-81
Pilarski LM, Giannakopoulos NV, Szczepek AJ, et al. (2000) In multiple myeloma, circulating hyperdiploid B cells have clonotypic immunoglobulin heavy chain rearrangements and may mediate spread of disease Clinical Cancer Research. 6: 585-596
Szczepek AJ, Seeberger K, Wizniak J, et al. (1998) A high frequency of circulating B cells share clonotypic Ig heavy-chain VDJ rearrangements with autologous bone marrow plasma cells in multiple myeloma, as measured by single-cell and in situ reverse transcriptase-polymerase chain reaction. Blood. 92: 2844-55
Pilarski LM, Szczepek AJ, Belch AR. (1997) Deficient drug transporter function of bone marrow-localized and leukemic plasma cells in multiple myeloma. Blood. 90: 3751-9
Szczepek AJ, Bergsagel PL, Axelsson L, et al. (1997) CD34+ cells in the blood of patients with multiple myeloma express CD19 and IgH mRNA and have patient-specific IgH VDJ gene rearrangements. Blood. 89: 1824-33
Szczepek A, Mant M, Belch A, et al. (1997) Circulating CD19+ cells in multiple myeloma are clonaly related to the end stage malignant plasma cells in the bone marrow Immunology Letters. 56: 327
Bergsagel P, Smith A, Szczepek A, et al. (1995) In multiple myeloma, clonotypic B lymphocytes are detectable among CD19+ peripheral blood cells expressing CD38, CD56, and monotypic Ig light chain [published erratum appears in Blood 1995 Jun 1;85(11):3365] Blood. 85: 436-447
Szczepek AJ, Belch AR, Pilarski LM. (1994) Interleukin-6 (IL-6) and interferon gamma (IFNγ) expression in peripheral blood lymphocytes (PBMC) from multiple myeloma patients Cytokine. 6: 570
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