Jayne M. Stommel, Ph.D.

2002 University of California, San Diego, La Jolla, CA 
Molecular Biology, Cell Biology
"Jayne Stommel"


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Geoffrey M. Wahl grad student 2002 UCSD
 (The regulation of p53 and MDM2 by nuclear -cytoplasmic shuttling and degradation.)
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Porter JR, Fisher BE, Baranello L, et al. (2017) Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. Molecular Cell
Inuzuka H, Tseng A, Gao D, et al. (2010) Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 18: 147-59
Zheng H, Ying H, Yan H, et al. (2008) Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harbor Symposia On Quantitative Biology. 73: 427-37
Zheng H, Ying H, Yan H, et al. (2008) p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 455: 1129-33
Wade M, Wong ET, Tang M, et al. (2006) Hdmx modulates the outcome of p53 activation in human tumor cells. The Journal of Biological Chemistry. 281: 33036-44
Stommel JM, Wahl GM. (2005) A new twist in the feedback loop: stress-activated MDM2 destabilization is required for p53 activation. Cell Cycle (Georgetown, Tex.). 4: 411-7
Stommel JM, Wahl GM. (2004) Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. The Embo Journal. 23: 1547-56
Jimenez GS, Nister M, Stommel JM, et al. (2000) A transactivation-deficient mouse model provides insights into Trp53 regulation and function. Nature Genetics. 26: 37-43
Jimenez GS, Khan SH, Stommel JM, et al. (1999) p53 regulation by post-translational modification and nuclear retention in response to diverse stresses. Oncogene. 18: 7656-65
Stommel JM, Marchenko ND, Jimenez GS, et al. (1999) A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. The Embo Journal. 18: 1660-72
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