Michael Laughrea

Affiliations: 
McGill University, Montreal, QC, Canada 
Area:
Molecular Biology, Pathology
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"Michael Laughrea"

Parents

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Donald M. Engelman grad student 1974-1978 (Chemistry Tree)
Peter B. Moore grad student 1974-1978 (Chemistry Tree)
Charles G. Kurland post-doc 1978-1979 (Chemistry Tree)
Joan A. Steitz research scientist 1977 (Chemistry Tree)
Marianne Grunberg-Manago research scientist 1978 (Chemistry Tree)

Children

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Ni Shen grad student 2003 McGill
Rujun Song grad student 2008 McGill
Jafar Kafaie grad student 2009 McGill
Mohammad Jalalalirad grad student 2013 McGill
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Publications

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Solis M, Nakhaei P, Jalalirad M, et al. (2011) RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. Journal of Virology. 85: 1224-36
Abrahamyan LG, Chatel-Chaix L, Ajamian L, et al. (2010) Novel Staufen1 ribonucleoproteins prevent formation of stress granules but favour encapsidation of HIV-1 genomic RNA. Journal of Cell Science. 123: 369-83
Kafaie J, Dolatshahi M, Ajamian L, et al. (2009) Role of capsid sequence and immature nucleocapsid proteins p9 and p15 in Human Immunodeficiency Virus type 1 genomic RNA dimerization. Virology. 385: 233-44
Kafaie J, Song R, Abrahamyan L, et al. (2008) Mapping of nucleocapsid residues important for HIV-1 genomic RNA dimerization and packaging. Virology. 375: 592-610
Song R, Kafaie J, Laughrea M. (2008) Role of the 5' TAR stem--loop and the U5-AUG duplex in dimerization of HIV-1 genomic RNA. Biochemistry. 47: 3283-93
Song R, Kafaie J, Yang L, et al. (2007) HIV-1 viral RNA is selected in the form of monomers that dimerize in a three-step protease-dependent process; the DIS of stem-loop 1 initiates viral RNA dimerization. Journal of Molecular Biology. 371: 1084-98
Rong L, Russell RS, Hu J, et al. (2003) Deletion of stem-loop 3 is compensated by second-site mutations within the Gag protein of human immunodeficiency virus type 1. Virology. 314: 221-8
Russell RS, Hu J, Bériault V, et al. (2003) Sequences downstream of the 5' splice donor site are required for both packaging and dimerization of human immunodeficiency virus type 1 RNA. Journal of Virology. 77: 84-96
Russell RS, Hu J, Laughrea M, et al. (2002) Deficient dimerization of human immunodeficiency virus type 1 RNA caused by mutations of the u5 RNA sequences. Virology. 303: 152-63
Shen N, Jetté L, Wainberg MA, et al. (2001) Role of stem B, loop B, and nucleotides next to the primer binding site and the kissing-loop domain in human immunodeficiency virus type 1 replication and genomic-RNA dimerization. Journal of Virology. 75: 10543-9
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