Valerie S. LeBleu, Ph.D.

Affiliations: 
2009 Harvard University, Cambridge, MA, United States 
Area:
Cell Biology
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"Valerie LeBleu"

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Raghu Kalluri grad student 2009 Harvard
 (The pathobiochemistry of Alport syndrome and mechanism of cell-based therapy.)
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Publications

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LeBleu VS, Kanasaki K, Lovisa S, et al. (2024) Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome. Life Science Alliance. 7
Laklai H, Miroshnikova YA, Pickup MW, et al. (2023) Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nature Medicine
Kugeratski FG, LeBleu VS, Dowlatshahi DP, et al. (2023) Engineered immunomodulatory extracellular vesicles derived from epithelial cells acquire capacity for positive and negative T cell co-stimulation in cancer and autoimmunity. Biorxiv : the Preprint Server For Biology
Mahadevan KK, LeBleu VS, Ramirez EV, et al. (2023) Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8 T cells. Developmental Cell
Mahadevan KK, McAndrews KM, LeBleu VS, et al. (2023) KRAS inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8 T cells. Cancer Cell
LeBleu VS, Dai J, Tsutakawa S, et al. (2023) Identification of unique α4 chain structure and conserved antiangiogenic activity of α3NC1 type IV collagen in zebrafish. Developmental Dynamics : An Official Publication of the American Association of Anatomists
Mahadevan KK, McAndrews KM, LeBleu VS, et al. (2023) Oncogenic Kras specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 T cells dependent manner. Biorxiv : the Preprint Server For Biology
Haltom AR, Hassen WE, Hensel J, et al. (2022) Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma. Extracellular Vesicle. 1
Melo SA, Luecke LB, Kahlert C, et al. (2022) Author Correction: Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature
LeBleu VS. (2022) Plasticity Enables Cooperation among Heterogeneous Cancer Cell Populations to Support Metastatic Fitness. Cancer Research. 82: 1870-1871
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