Valerie S. LeBleu, Ph.D.

2009 Harvard University, Cambridge, MA, United States 
Cell Biology
"Valerie LeBleu"


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Raghu Kalluri grad student 2009 Harvard
 (The pathobiochemistry of Alport syndrome and mechanism of cell-based therapy.)
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LeBleu VS, Dai J, Tsutakawa S, et al. (2023) Identification of unique α4 chain structure and conserved antiangiogenic activity of α3NC1 type IV collagen in zebrafish. Developmental Dynamics : An Official Publication of the American Association of Anatomists
Mahadevan KK, McAndrews KM, LeBleu VS, et al. (2023) Oncogenic Kras specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 T cells dependent manner. Biorxiv : the Preprint Server For Biology
Melo SA, Luecke LB, Kahlert C, et al. (2022) Author Correction: Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature
LeBleu VS. (2022) Plasticity Enables Cooperation among Heterogeneous Cancer Cell Populations to Support Metastatic Fitness. Cancer Research. 82: 1870-1871
McAndrews KM, Chen Y, Darpolor JK, et al. (2022) Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL-6 Mediated Therapy Resistance in Pancreatic Cancer. Cancer Discovery
McAndrews KM, Miyake T, Ehsanipour EA, et al. (2022) Dermal αSMA myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production. The Embo Journal. e109470
El-Shennawy L, Hoffmann AD, Dashzeveg NK, et al. (2022) Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2. Nature Communications. 13: 405
Zhou X, Kurywchak P, Wolf-Dennen K, et al. (2021) Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer. Molecular Therapy. Methods & Clinical Development. 22: 360-376
McAndrews KM, Xiao F, Chronopoulos A, et al. (2021) Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic Kras in pancreatic cancer. Life Science Alliance. 4
McAndrews KM, Vázquez-Arreguín K, Kwak C, et al. (2021) αSMA fibroblasts suppress Lgr5 cancer stem cells and restrain colorectal cancer progression. Oncogene
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