Joseph P. Tiano, Ph.D.

Affiliations: 
2012 Integrated Graduate Program in the Life Sciences Northwestern University, Evanston, IL 
Area:
General Biology, Endocrinology Biology, Molecular Biology, Cell Biology
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"Joseph Tiano"

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Franck Mauvais-Jarvis grad student 2012 Northwestern
 (Estrogen Receptor Activation Suppresses Lipogenesis and Reduces Lipid Accumulation in Pancreatic Islets and Prevents Lipotoxic beta-cell Failure.)
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Publications

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Fuselier T, Mota de Sa P, Qadir MMF, et al. (2022) Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes. Cell Reports. Medicine. 3: 100598
Zhou Z, Ribas V, Rajbhandari P, et al. (2018) Estrogen receptor alpha protects pancreatic beta cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. The Journal of Biological Chemistry
Mauvais-Jarvis F, Le May C, Tiano JP, et al. (2017) The Role of Estrogens in Pancreatic Islet Physiopathology. Advances in Experimental Medicine and Biology. 1043: 385-399
Tiano JP, Tate CR, Yang BS, et al. (2015) Effect of targeted estrogen delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis. Scientific Reports. 5: 10211
Tiano JP, Springer DA, Rane SG. (2015) SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise. The Journal of Biological Chemistry. 290: 7671-84
Tiano JP, Tate CR, Yang BS, et al. (2015) Effect of targeted estrogen delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis Scientific Reports. 5
Finan B, Yang B, Ottaway N, et al. (2012) Targeted estrogen delivery reverses the metabolic syndrome. Nature Medicine. 18: 1847-56
Tiano JP, Mauvais-Jarvis F. (2012) Molecular mechanisms of estrogen receptors' suppression of lipogenesis in pancreatic β-cells. Endocrinology. 153: 2997-3005
Tiano J, Mauvais-Jarvis F. (2012) Selective estrogen receptor modulation in pancreatic β-cells and the prevention of type 2 diabetes. Islets. 4: 173-6
Tiano JP, Mauvais-Jarvis F. (2012) Importance of oestrogen receptors to preserve functional β-cell mass in diabetes. Nature Reviews. Endocrinology. 8: 342-51
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