Eric M. Tam, Ph.D.
Affiliations: | 2005 | University of British Columbia, Vancouver, Vancouver, BC, Canada |
Area:
Molecular BiologyGoogle:
"Eric Tam"Parents
Sign in to add mentor| Christopher M. Overall | grad student | 2005 | UBC | |
| (Matrix metalloproteinase substrate recognition, characterization and proteomic discovery.) | ||||
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Publications
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| Tam EM, Runyon ST, Santell L, et al. (2009) Noncompetitive inhibition of hepatocyte growth factor-dependent Met signaling by a phage-derived peptide. Journal of Molecular Biology. 385: 79-90 |
| Butler GS, Dean RA, Tam EM, et al. (2008) Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding. Molecular and Cellular Biology. 28: 4896-914 |
| Wolf K, Wu YI, Liu Y, et al. (2007) Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nature Cell Biology. 9: 893-904 |
| Iida J, Wilhelmson KL, Ng J, et al. (2007) Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A). The Biochemical Journal. 403: 553-63 |
| Tam EM, Moore TR, Butler GS, et al. (2004) Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in collagen triple helicase activities. The Journal of Biological Chemistry. 279: 43336-44 |
| Overall CM, Tam EM, Kappelhoff R, et al. (2004) Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors. Biological Chemistry. 385: 493-504 |
| Tam EM, Morrison CJ, Wu YI, et al. (2004) Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. Proceedings of the National Academy of Sciences of the United States of America. 101: 6917-22 |
| Butler GS, Tam EM, Overall CM. (2004) The canonical methionine 392 of matrix metalloproteinase 2 (gelatinase A) is not required for catalytic efficiency or structural integrity: probing the role of the methionine-turn in the metzincin metalloprotease superfamily. The Journal of Biological Chemistry. 279: 15615-20 |
| Tam EM, Wu YI, Butler GS, et al. (2002) Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage. The Journal of Biological Chemistry. 277: 39005-14 |
| Butler GS, Sim D, Tam E, et al. (2002) Mannose-binding lectin (MBL) mutants are susceptible to matrix metalloproteinase proteolysis: potential role in human MBL deficiency. The Journal of Biological Chemistry. 277: 17511-9 |