Alisha Holtzhausen, Ph.D.
Affiliations: | 2013 | Molecular Cancer Biology | Duke University, Durham, NC |
Area:
Molecular Biology, Oncology, Cell BiologyGoogle:
"Alisha Holtzhausen"Parents
Sign in to add mentor| Gerard C. Blobe | grad student | 2013 | Duke | |
| (Bone morphogenetic proteins signal through Smad1/5/8 to induce MET, Smad2 to specify the dorsoventral axis and Smad3 to facilitate invasion.) | ||||
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Publications
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| Plebanek MP, Xue Y, Nguyen YV, et al. (2023) A SREBF2-dependent gene program drives an immunotolerant dendritic cell population during cancer progression. Biorxiv : the Preprint Server For Biology |
| Theivanthiran B, Yarla N, Haykal T, et al. (2022) Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti-PD-1 immunotherapy. Science Translational Medicine. 14: eabq7019 |
| Theivanthiran B, Haykal T, Cao L, et al. (2021) Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis. Cancers. 13 |
| DeVito NC, Sturdivant M, Thievanthiran B, et al. (2021) Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy. Cell Reports. 35: 109071 |
| Holtzhausen A, Harris W, Ubil E, et al. (2019) TAM Family Receptor kinase inhibition reverses MDSC-mediated suppression and augments anti-PD-1 therapy in melanoma. Cancer Immunology Research |
| Zhao F, Evans KS, Xiao C, et al. (2018) Stromal Fibroblasts Mediate Anti-PD-1 Resistance via MMP-9 and Dictate TGF-β Inhibitor Sequencing in Melanoma. Cancer Immunology Research |
| Porrello A, Leslie PL, Harrison EB, et al. (2018) Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking. Nature Communications. 9: 1988 |
| Ubil E, Caskey L, Holtzhausen A, et al. (2018) Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. The Journal of Clinical Investigation |
| Zhao F, Xiao C, Evans KS, et al. (2018) Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization. Immunity. 48: 147-160.e7 |
| Holtzhausen A, Zhao F, Evans K, et al. (2015) Melanoma-derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy. Cancer Immunology Research |