Hestia S. Mellert, Ph.D.

Affiliations: 
2011 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Cell Biology
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"Hestia Mellert"

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Steven B. McMahon grad student 2011 Penn
 (Regulating p53-mediated apoptosis by modulating DNA-binding domain acetylation.)
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Publications

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Oran AR, Adams CM, Zhang XY, et al. (2016) Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget
Monteith JA, Mellert H, Sammons MA, et al. (2016) A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction. Molecular Oncology
Thangavel C, Boopathi E, Ciment S, et al. (2014) The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 5468-82
Allen MA, Andrysik Z, Dengler VL, et al. (2014) Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms. Elife. 3: e02200
Mellert H, Espinosa JM. (2013) Tumor suppression by p53: is apoptosis important or not? Cell Reports. 3: 1335-6
Den RB, Ciment S, Sharma A, et al. (2012) Differential response of prostate cancer cells to ionizing radiation: The RB status. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 106
Yuan H, Rossetto D, Mellert H, et al. (2012) MYST protein acetyltransferase activity requires active site lysine autoacetylation. The Embo Journal. 31: 58-70
Den RB, Ciment S, Sharma A, et al. (2011) Relationship between the loss of the retinoblastoma tumor suppressor and radiosensitivity. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 34
Zhang XY, Pfeiffer HK, Mellert HS, et al. (2011) Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC. Molecular and Cellular Biology. 31: 5037-45
Charvet C, Wissler M, Brauns-Schubert P, et al. (2011) Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Molecular Cell. 42: 584-96
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