Shyam Ramchandani, Ph.D.

Affiliations: 
2000 McGill University, Montreal, QC, Canada 
Area:
Pharmacology, Oncology
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"Shyam Ramchandani"

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Moshe Szyf grad student 2000 McGill
 (Identification of the DNA methylation machinery, its regulation and uses as potential anticancer therapeutics.)
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Publications

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Slack A, Bovenzi V, Bigey P, et al. (2002) Antisense MBD2 gene therapy inhibits tumorigenesis Journal of Gene Medicine. 4: 381-389
Detich N, Ramchandani S, Szyf M. (2001) A conserved 3'-untranslated element mediates growth regulation of DNA methyltransferase 1 and inhibits its transforming activity. The Journal of Biological Chemistry. 276: 24881-90
Bigey P, Ramchandani S, Theberge J, et al. (2000) Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene. Gene. 242: 407-18
Ramchandani S, Bhattacharya SK, Cervoni N, et al. (1999) DNA methylation is a reversible biological signal. Proceedings of the National Academy of Sciences of the United States of America. 96: 6107-12
Araujo FD, Knox JD, Ramchandani S, et al. (1999) Identification of initiation sites for DNA replication in the human dnmt1 (DNA-methyltransferase) locus. The Journal of Biological Chemistry. 274: 9335-41
Bhattacharya SK, Ramchandani S, Cervoni N, et al. (1999) A mammalian protein with specific demethylase activity for mCpG DNA. Nature. 397: 579-83
Ramchandani S, Bigey P, Szyf M. (1998) Genomic structure of the human DNA methyltransferase gene. Biological Chemistry. 379: 535-40
Ramchandani S, MacLeod AR, Pinard M, et al. (1997) Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide. Proceedings of the National Academy of Sciences of the United States of America. 94: 684-9
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