Dallas Flies, Ph.D.

Affiliations: 
2010 Johns Hopkins University, Baltimore, MD 
Area:
Immunology
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"Dallas Flies"

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Lieping Chen grad student 2010 Johns Hopkins
 (Identification and characterization of regulator of T lymphocyte activation (RTLA), a novel co-signaling molecule.)
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Publications

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Prajapati K, Yan C, Yang Q, et al. (2024) The FLRT3-UNC5B checkpoint pathway inhibits T cell-based cancer immunotherapies. Science Advances. 10: eadj4698
Wang Q, He J, Flies DB, et al. (2023) Author Correction: Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability. Scientific Reports. 13: 11603
Vijver SV, Singh A, Mommers-Elshof ETAM, et al. (2021) Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1. Frontiers in Immunology. 12: 733561
Ramos MIP, Tian L, de Ruiter EJ, et al. (2021) Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction. Elife. 10
Han X, Vesely MD, Yang W, et al. (2019) PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus. Science Translational Medicine. 11
Wang J, Sun J, Liu LN, et al. (2019) Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature Medicine
Wang Q, He J, Flies DB, et al. (2017) Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability. Scientific Reports. 7: 6086
Flies DB, Higuchi T, Harris JC, et al. (2016) Immune checkpoint blockade reveals the stimulatory capacity of tumor-associated CD103(+) dendritic cells in late-stage ovarian cancer. Oncoimmunology. 5: e1185583
Higuchi T, Flies DB, Marjon NA, et al. (2015) CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer. Cancer Immunology Research. 3: 1257-68
Flies DB, Higuchi T, Chen L. (2015) Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens. Journal of Immunology (Baltimore, Md. : 1950). 194: 5294-304
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