Hiroshi Handa, M.D. Ph.D

Biological Informations Tokyo Institute of Technology, Yokohama-shi, Kanagawa-ken, Japan 
Transcription, virus, chemical biology
"Hiroshi Handa"


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Sittinan Chanarat grad student (Physics Tree)


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Satoshi Inouye collaborator (Chemistry Tree)
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Yamamoto J, Suwa T, Murase Y, et al. (2020) ARID2 is a pomalidomide-dependent CRL4 substrate in multiple myeloma cells. Nature Chemical Biology
Tateno S, Iida M, Fujii S, et al. (2020) Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide. Scientific Reports. 10: 4012
Ando H, Sato T, Ito T, et al. (2019) Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. Iscience. 15: 95-108
Ito T, Handa H. (2017) Recent topics in IMiDs and cereblon. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology. 58: 2067-2073
Boccitto M, Lee N, Sakamoto S, et al. (2017) The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK. Marine Drugs. 15
Matyskiela M, Lu G, Ito T, et al. (2017) Abstract SY37-02: Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects Cancer Research. 77
Kabe Y, Yamamoto T, Kajimura M, et al. (2016) Cystathionine beta-synthase and PGRMC1 as CO sensors. Free Radical Biology & Medicine
Matyskiela ME, Lu G, Ito T, et al. (2016) A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature
Nguyen TV, Lee JE, Sweredoski MJ, et al. (2016) Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Molecular Cell. 61: 809-820
Harama D, Tamai M, Inukai T, et al. (2016) Lenalidomide Effectively Induces Philadelphia-Chromosome Positive ALL Cells into Apoptosis in Synergy with Tyrosine Kinase Inhibitor Blood. 128: 1060-1060
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