Christopher M. Hosfield, Ph.D.

Affiliations: 
2001 Queen's University, Canada, Kingston, Ontario, Canada 
Area:
Molecular Biology
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"Christopher Hosfield"

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Zongchao Jia grad student 2001 Queen's University, Canada
 (Crystal structure and regulatory mechanism of calpain: Insights into calcium-dependent proteolysis.)
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Publications

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Hosfield CM, Elce JS, Jia Z. (2004) Activation of calpain by Ca2+: roles of the large subunit N-terminal and domain III-IV linker peptides. Journal of Molecular Biology. 343: 1049-53
Moldoveanu T, Hosfield CM, Lim D, et al. (2003) Calpain silencing by a reversible intrinsic mechanism. Nature Structural Biology. 10: 371-8
Moldoveanu T, Hosfield CM, Lim D, et al. (2002) A Ca(2+) switch aligns the active site of calpain. Cell. 108: 649-60
Jia Z, Hosfield CM, Davies PL, et al. (2002) Crystal structure of calpain and insights into Ca(2+)-dependent activation. Methods in Molecular Biology (Clifton, N.J.). 172: 51-67
Moldoveanu T, Hosfield CM, Jia Z, et al. (2001) Ca(2+)-induced structural changes in rat m-calpain revealed by partial proteolysis. Biochimica Et Biophysica Acta. 1545: 245-54
Hosfield CM, Moldoveanu T, Davies PL, et al. (2001) Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C(2)-like domain. The Journal of Biological Chemistry. 276: 7404-7
Hosfield CM, Elce JS, Davies PL, et al. (1999) Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation. The Embo Journal. 18: 6880-9
Hosfield CM, Ye Q, Arthur JS, et al. (1999) Crystallization and X-ray crystallographic analysis of m-calpain, a Ca2+-dependent protease. Acta Crystallographica. Section D, Biological Crystallography. 55: 1484-6
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