Sean R. Christensen, Ph.D.

Affiliations: 
2006 Yale University, New Haven, CT 
Area:
Immunology, Pathology
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"Sean Christensen"

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Mark Shlomchik grad student 2006 Yale
 (B cells at the interface of innate and adaptive immunity in systemic lupus erythematosus: Requirements for the activation of autoreactive B cells in autoimmune disease.)
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Publications

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Nickerson KM, Christensen SR, Cullen JL, et al. (2013) TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation. Journal of Immunology (Baltimore, Md. : 1950). 190: 1447-56
Sweet RA, Christensen SR, Harris ML, et al. (2010) A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation. Autoimmunity. 43: 607-18
Nickerson KM, Christensen SR, Shupe J, et al. (2010) TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. Journal of Immunology (Baltimore, Md. : 1950). 184: 1840-8
Avalos AM, Latz E, Mousseau B, et al. (2009) Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides. Journal of Immunology (Baltimore, Md. : 1950). 183: 6262-8
Green NM, Laws A, Kiefer K, et al. (2009) Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. Journal of Immunology (Baltimore, Md. : 1950). 183: 1569-76
Uccellini MB, Busconi L, Green NM, et al. (2008) Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha. Journal of Immunology (Baltimore, Md. : 1950). 181: 5875-84
Herlands RA, Christensen SR, Sweet RA, et al. (2008) T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity. 29: 249-60
Christensen SR, Shlomchik MJ. (2007) Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors. Seminars in Immunology. 19: 11-23
Christensen SR, Shupe J, Nickerson K, et al. (2006) Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity. 25: 417-28
Lau CM, Broughton C, Tabor AS, et al. (2005) RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. The Journal of Experimental Medicine. 202: 1171-7
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