Gary Silverman

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Molecular Biology, Genetics
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"Gary Silverman"
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Li J, Moretti F, Hidvegi T, et al. (2024) Multiple genes core to ERAD, macro-autophagy and lysosomal degradation pathways participate in the proteostasis response in α1-antitrypsin deficiency. Cellular and Molecular Gastroenterology and Hepatology
Shi Q, Pei F, Silverman GA, et al. (2020) Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis. International Journal of Molecular Sciences. 21
Wang S, Luke C, Shi V, et al. (2020) Abstract 2426: SERPINB3 promotes radiation resistance in cervical cancer by inhibiting lysosome-mediated cell death Cancer Research. 80: 2426-2426
Wang Y, Cobanoglu MC, Li J, et al. (2019) An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z. Plos One. 14: e0209748
Cummings EE, O'Reilly LP, King DE, et al. (2015) Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency. Plos One. 10: e0141542
Long OS, Benson JA, Kwak JH, et al. (2014) A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover. Human Molecular Genetics. 23: 5109-22
O'Reilly LP, Long OS, Cobanoglu MC, et al. (2014) A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency. Human Molecular Genetics. 23: 5123-32
Li J, Pak SC, O'Reilly LP, et al. (2014) Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency. Plos One. 9: e87260
O'Reilly LP, Perlmutter DH, Silverman GA, et al. (2014) α1-antitrypsin deficiency and the hepatocytes - an elegans solution to drug discovery. The International Journal of Biochemistry & Cell Biology. 47: 109-12
O'Reilly LP, Luke CJ, Perlmutter DH, et al. (2014) C. elegans in high-throughput drug discovery. Advanced Drug Delivery Reviews. 69: 247-53
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