Markus A. Seeliger
Affiliations: | Molecular and Cellular Pharmacology | Stony Brook University, Stony Brook, NY, United States |
Area:
Pharmacy, Molecular BiologyGoogle:
"Markus Seeliger"Parents
Sign in to add mentor| Alan Roy Fersht | grad student | (Chemistry Tree) | |
| John Kuriyan | post-doc | UC Berkeley (Chemistry Tree) |
Children
Sign in to add trainee| George Georghiou | grad student | 2014 | SUNY Stony Brook |
| Sukrit Singh | post-doc | Stony Brook University Medical Center (Chemistry Tree) |
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Publications
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| Lee JY, Gebauer E, Seeliger MA, et al. (2024) Allo-targeting of the kinase domain: Insights from in silico studies and comparison with experiments. Current Opinion in Structural Biology. 84: 102770 |
| Outhwaite IR, Singh S, Berger BT, et al. (2023) Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting. Elife. 12 |
| Outhwaite IR, Seeliger MA. (2023) Probing conformational dynamics to understand kinase inhibition. Elife. 12 |
| Ayaz P, Lyczek A, Paung Y, et al. (2023) Structural mechanism of a drug-binding process involving a large conformational change of the protein target. Nature Communications. 14: 1885 |
| Kan Y, Paung Y, Seeliger MA, et al. (2023) Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1. Cells. 12 |
| Kan Y, Paung Y, Kim Y, et al. (2023) Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk. Biochemistry |
| Mingione VR, Paung Y, Outhwaite IR, et al. (2023) Allosteric regulation and inhibition of protein kinases. Biochemical Society Transactions. 51: 373-385 |
| Outhwaite IR, Singh S, Berger BT, et al. (2023) Death by a Thousand Cuts â€" Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology. Biorxiv : the Preprint Server For Biology |
| Sridaran D, Chouhan S, Mahajan K, et al. (2022) Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Nature Communications. 13: 6929 |
| Peterson AA, Rangwala AM, Thakur MK, et al. (2022) Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nature Chemical Biology |