Rachelle Kosoff

Affiliations: 
2008-2013 University of Pennsylvania, Philadelphia, PA, United States 
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"Rachelle Kosoff"
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Publications

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Thapa RJ, Ingram JP, Ragan KB, et al. (2016) DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death. Cell Host & Microbe
Nogusa S, Thapa RJ, Dillon CP, et al. (2016) RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. Cell Host & Microbe
Kosoff RE, Aslan JE, Kostyak JC, et al. (2015) Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization. Blood. 125: 2995-3005
Zeng Y, Broxmeyer HE, Staser K, et al. (2015) Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation. Stem Cells (Dayton, Ohio). 33: 1630-41
Phee H, Au-Yeung BB, Pryshchep O, et al. (2014) Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. Elife. 3: e02270
Radu M, Semenova G, Kosoff R, et al. (2014) PAK signalling during the development and progression of cancer. Nature Reviews. Cancer. 14: 13-25
Phee H, Au-Yeung BB, Pryshchep O, et al. (2014) Author response: Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation Elife
Dorrance AM, De Vita S, Radu M, et al. (2013) The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood. 121: 2474-82
Kosoff R, Chow HY, Radu M, et al. (2013) Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity. The Journal of Biological Chemistry. 288: 974-83
Reddy PN, Wood J, Harris CE, et al. (2013) Kinase Activity Of Pak2, An Effector Of Rac/CDC42 and Its Interaction With β-PIX Is Required For Murine Hematopoietic Stem Cell Shape, F-Actin Formation, Directional Migration In Vitro and For HSPC Homing To Bone Marrow In Vivo Blood. 122: 2419-2419
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