Alexandra M. Deaconescu, Ph.D.
Affiliations: | Brandeis University, Waltham, MA, United States | ||
| 2014- | Molecular Biology, Cell Biology and Biochemistry | Brown University, Providence, RI |
Area:
biochemistry, x-ray crystallography, TEMWebsite:
http://www.deaconesculab.com/Google:
"Alexandra Deaconescu"Cross-listing: Chemistry Tree
Parents
Sign in to add mentor| Stephen K. Burley | research assistant | Rockefeller (Physics Tree) | ||
| Robert Q. Topper | research assistant | The Cooper Union (Chemistry Tree) | ||
| (publication) | ||||
| Nikolaus Grigorieff | post-doc | Brandeis (Evolution Tree) | ||
Children
Sign in to add trainee| Victoria Dorich | research assistant | Brown (Chemistry Tree) | |
| Jacob Schwartz | research assistant | Brown (Chemistry Tree) | |
| Margaret Suhanovsky | post-doc | Brown (Chemistry Tree) | |
| Christiane Brugger | post-doc | 2018- | Brown (Chemistry Tree) |
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Publications
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| Brugger C, Srirangam S, Deaconescu AM. (2023) IraM Remodels the RssB Segmented Helical Linker to Stabilize σ Against Degradation by ClpXP. The Journal of Biological Chemistry. 105568 |
| Brugger C, Schwartz J, Novick S, et al. (2023) Structure of Phosphorylated-like RssB, the Adaptor Delivering σ to the ClpXP Proteolytic Machinery, Reveals an Interface Switch for Activation. The Journal of Biological Chemistry. 105440 |
| Vadgama N, Kreymerman A, Campbell J, et al. (2022) SARS-CoV-2 Susceptibility and Gene Variations Within Diverse Ethnic Backgrounds. Frontiers in Genetics. 13: 888025 |
| Deaconescu AM. (2021) Mfd - at the crossroads of bacterial DNA repair, transcriptional regulation and molecular evolvability. Transcription. 12: 156-170 |
| Brugger C, Deaconescu AM. (2021) A Gel-Based Assay for Probing Protein Translocation on dsDNA. Bio-Protocol. 11: e4094 |
| Schwartz J, Son J, Brugger C, et al. (2021) Phospho-dependent Signaling during the General Stress Response by the Atypical Response Regulator and ClpXP Adaptor RssB. Protein Science : a Publication of the Protein Society |
| Brugger C, Zhang C, Suhanovsky MM, et al. (2020) Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd. Nature Communications. 11: 3740 |
| Dorich V, Brugger C, Tripathi A, et al. (2019) Structural basis for inhibition of a response regulator of σ stability by a ClpXP antiadaptor. Genes & Development |
| Vemu A, Szczesna E, Zehr EA, et al. (2018) Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation. Science (New York, N.Y.). 361 |
| Le TT, Yang Y, Tan C, et al. (2018) Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism. Cell. 173: 1823 |