Alexandra M. Deaconescu, Ph.D.

Affiliations: 
Brandeis University, Waltham, MA, United States 
 2014- Molecular Biology, Cell Biology and Biochemistry Brown University, Providence, RI 
Area:
biochemistry, x-ray crystallography, TEM
Website:
http://www.deaconesculab.com/
Google:
"Alexandra Deaconescu"
Cross-listing: Chemistry Tree

Parents

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Stephen K. Burley research assistant Rockefeller (Physics Tree)
Robert Q. Topper research assistant The Cooper Union (Chemistry Tree)
 (publication)
Nikolaus Grigorieff post-doc Brandeis (Evolution Tree)

Children

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Victoria Dorich research assistant Brown (Chemistry Tree)
Jacob Schwartz research assistant Brown (Chemistry Tree)
Margaret Suhanovsky post-doc Brown (Chemistry Tree)
Christiane Brugger post-doc 2018- Brown (Chemistry Tree)
BETA: Related publications

Publications

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Brugger C, Srirangam S, Deaconescu AM. (2023) IraM Remodels the RssB Segmented Helical Linker to Stabilize σ Against Degradation by ClpXP. The Journal of Biological Chemistry. 105568
Brugger C, Schwartz J, Novick S, et al. (2023) Structure of Phosphorylated-like RssB, the Adaptor Delivering σ to the ClpXP Proteolytic Machinery, Reveals an Interface Switch for Activation. The Journal of Biological Chemistry. 105440
Vadgama N, Kreymerman A, Campbell J, et al. (2022) SARS-CoV-2 Susceptibility and Gene Variations Within Diverse Ethnic Backgrounds. Frontiers in Genetics. 13: 888025
Deaconescu AM. (2021) Mfd - at the crossroads of bacterial DNA repair, transcriptional regulation and molecular evolvability. Transcription. 12: 156-170
Brugger C, Deaconescu AM. (2021) A Gel-Based Assay for Probing Protein Translocation on dsDNA. Bio-Protocol. 11: e4094
Schwartz J, Son J, Brugger C, et al. (2021) Phospho-dependent Signaling during the General Stress Response by the Atypical Response Regulator and ClpXP Adaptor RssB. Protein Science : a Publication of the Protein Society
Brugger C, Zhang C, Suhanovsky MM, et al. (2020) Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd. Nature Communications. 11: 3740
Dorich V, Brugger C, Tripathi A, et al. (2019) Structural basis for inhibition of a response regulator of σ stability by a ClpXP antiadaptor. Genes & Development
Vemu A, Szczesna E, Zehr EA, et al. (2018) Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation. Science (New York, N.Y.). 361
Le TT, Yang Y, Tan C, et al. (2018) Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism. Cell. 173: 1823
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