Weng C. Man, Ph.D.

2006 University of Wisconsin, Madison, Madison, WI 
Molecular Biology
"Weng Man"


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James M. Ntambi grad student 2006 UW Madison
 (Topology of stearoyl -CoA desaturase 1 and its co-localization with acyl -CoA diacylglycerol acyltransferase 2 in endoplasmic reticulum.)
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Chu K, Miyazaki M, Man WC, et al. (2006) Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Molecular and Cellular Biology. 26: 6786-98
Man WC, Miyazaki M, Chu K, et al. (2006) Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. Journal of Lipid Research. 47: 1928-39
Man WC, Miyazaki M, Chu K, et al. (2006) Membrane topology of mouse stearoyl-CoA desaturase 1. The Journal of Biological Chemistry. 281: 1251-60
Miyazaki M, Dobrzyn A, Man WC, et al. (2004) Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. The Journal of Biological Chemistry. 279: 25164-71
Miyazaki M, Jacobson MJ, Man WC, et al. (2003) Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. The Journal of Biological Chemistry. 278: 33904-11
Kim HJ, Miyazaki M, Man WC, et al. (2002) Sterol regulatory element-binding proteins (SREBPs) as regulators of lipid metabolism: polyunsaturated fatty acids oppose cholesterol-mediated induction of SREBP-1 maturation. Annals of the New York Academy of Sciences. 967: 34-42
Miyazaki M, Man WC, Ntambi JM. (2001) Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. The Journal of Nutrition. 131: 2260-8
Miyazaki M, Kim HJ, Man WC, et al. (2001) Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol. The Journal of Biological Chemistry. 276: 39455-61
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