Kiki Chu, Ph.D.

Affiliations: 
2008 University of Wisconsin, Madison, Madison, WI 
Area:
Molecular Biology
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"Kiki Chu"

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James M. Ntambi grad student 2008 UW Madison
 (Stearoyl -CoA desaturase 1: Transcriptional regulation by liver X receptor and its role in very low -density lipoprotein metabolism.)
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Publications

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Liu X, Miyazaki M, Flowers MT, et al. (2010) Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 31-8
Sampath H, Flowers MT, Liu X, et al. (2009) Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. The Journal of Biological Chemistry. 284: 19961-73
Miyazaki M, Sampath H, Liu X, et al. (2009) Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochemical and Biophysical Research Communications. 380: 818-22
Miyazaki M, Flowers MT, Sampath H, et al. (2007) Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metabolism. 6: 484-96
Chu K, Miyazaki M, Man WC, et al. (2006) Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Molecular and Cellular Biology. 26: 6786-98
Man WC, Miyazaki M, Chu K, et al. (2006) Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. Journal of Lipid Research. 47: 1928-39
Man WC, Miyazaki M, Chu K, et al. (2006) Membrane topology of mouse stearoyl-CoA desaturase 1. The Journal of Biological Chemistry. 281: 1251-60
Dobrzyn A, Dobrzyn P, Miyazaki M, et al. (2005) Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. The Journal of Biological Chemistry. 280: 23356-62
Miyazaki M, Dobrzyn A, Sampath H, et al. (2004) Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha. The Journal of Biological Chemistry. 279: 35017-24
Miyazaki M, Dobrzyn A, Man WC, et al. (2004) Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. The Journal of Biological Chemistry. 279: 25164-71
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