Sebastian Springer
Affiliations: | Jacobs University Bremen, Bremen, Bremen, Germany |
Area:
Biochemistry, Cell Biology, Immunology, Major Histocompatibility Complex Class I Molecules, Ligand Binding, Natively Unfolded Proteins, ImmunobiotechnologyGoogle:
"Sebastian Springer"Cross-listing: Chemistry Tree
Parents
Sign in to add mentor| Stefan Jentsch | research assistant | 1991-1992 | Friedrich Miescher Laboratory of the Max Planck Society | |
| (Searched for E3 ubiquitin conjugating enzymes) | ||||
| Alain R.M. Townsend | grad student | 1992-1996 | Oxford (Chemistry Tree) | |
| (Found that MHC class I proteins change their conformation when binding peptide) | ||||
| Randy W. Schekman | post-doc | 1996-2001 | UC Berkeley | |
| (Found that SNAREs interact with the COPII coat) | ||||
Children
Sign in to add trainee| Patrycja Kozik | research assistant | MRC-LMB (Chemistry Tree) | |
| Mohammed Al-Balushi | grad student | Sultan Qaboos University, Oman (Chemistry Tree) | |
| Susanne Fritzsche | grad student | Jacobs University Bremen | |
| Malgorzata (Gosia) A. Garstka | grad student | Xi'an Jiaotong University, PR China (Chemistry Tree) | |
| Esther Ghanem | grad student | Notre Dame University, Louaize, Lebanon (Chemistry Tree) | |
| Jood Hashem | grad student | University of Jordan (Chemistry Tree) | |
| Zeynep Hein | post-doc | 2009- | Jacobs University Bremen (Chemistry Tree) |
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Publications
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| Hartman K, Steiner G, Siegel M, et al. (2023) Expanding the MAPPs Assay to Accommodate MHC-II Pan Receptors for Improved Predictability of Potential T Cell Epitopes. Biology. 12 |
| Kuiper JJ, Prinz JC, Stratikos E, et al. (2023) EULAR study group on 'MHC-I-opathy': identifying disease-overarching mechanisms across disciplines and borders. Annals of the Rheumatic Diseases |
| Saikia A, Hadeler A, Prasad P, et al. (2022) Fast peptide exchange on MHC class I molecules by acidic stabilization of a peptide-empty intermediate. Protein Science : a Publication of the Protein Society. e4478 |
| Hadeler A, Saikia A, Zacharias M, et al. (2022) Rapid peptide exchange on MHC class I by small molecules elucidates dynamics of bound peptide. Current Research in Immunology. 3: 167-174 |
| Walters LC, Rozbesky D, Harlos K, et al. (2022) Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes. Cell Reports. 39: 110959 |
| Ruggiero FM, Springer S. (2022) Homotypic and heterotypic associations of MHC class I molecules at the cell surface. Current Research in Immunology. 3: 85-99 |
| Kopicki JD, Saikia A, Niebling S, et al. (2022) Opening opportunities for K determination and screening of MHC peptide complexes. Communications Biology. 5: 488 |
| Dirscherl C, Löchte S, Hein Z, et al. (2022) Dissociation of β2m from MHC class I Triggers formation of Noncovalent, transient heavy chain dimers. Journal of Cell Science |
| Kulicke CA, De Zan E, Hein Z, et al. (2021) The P5-type ATPase ATP13A1 modulates major histocompatibility complex I-related protein 1 (MR1)-mediated antigen presentation. The Journal of Biological Chemistry. 101542 |
| Springer S. (2021) Reply to "Identification of thermodynamic quantities of the stability of peptide-MHC I complex using nanoscale differential scanning fluorimetry" by Jakob Harris and Jonghoon Kang. Molecular Immunology. 141: 257 |