Richard L Frock

Stanford University, Palo Alto, CA 
DSB repair, immunology, chromosome translocation
"Richard Frock"
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Layer JV, Cleary JP, Brown AJ, et al. (2018) Parp3 promotes long-range end joining in murine cells. Proceedings of the National Academy of Sciences of the United States of America
Paulsen BS, Mandal PK, Frock RL, et al. (2017) Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing. Nature Biomedical Engineering. 1: 878-888
Willis NA, Frock RL, Menghi F, et al. (2017) Mechanism of tandem duplication formation in BRCA1-mutant cells. Nature
Kumar V, Alt FW, Frock RL. (2016) PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line. Proceedings of the National Academy of Sciences of the United States of America
Zhao L, Frock RL, Du Z, et al. (2016) Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. The Journal of Experimental Medicine
Hu J, Meyers RM, Dong J, et al. (2016) Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nature Protocols. 11: 853-71
Hu J, Zhang Y, Zhao L, et al. (2015) Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes. Cell. 163: 947-59
Frock RL, Hu J, Meyers RM, et al. (2015) Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nature Biotechnology. 33: 179-86
Frock RL, Chen SC, Da DF, et al. (2012) Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice. Plos One. 7: e42918
Chiarle R, Zhang Y, Frock RL, et al. (2011) Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell. 147: 107-19
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