Tatsuya Hirano, Ph. D.

1995-2007 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
 2007- RIKEN 
Cell biology; Biochemistry; Chromosomes; Condensins
"Tatsuya Hirano"
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Yoshida MM, Kinoshita K, Aizawa Y, et al. (2022) Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays. Elife. 11
Yamazaki H, Takagi M, Kosako H, et al. (2022) Cell cycle-specific phase separation regulated by protein charge blockiness. Nature Cell Biology. 24: 625-632
Kinoshita K, Tsubota Y, Tane S, et al. (2022) A loop extrusion-independent mechanism contributes to condensin I-mediated chromosome shaping. The Journal of Cell Biology. 221
Shintomi K, Hirano T. (2021) Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly. Nature Communications. 12: 2917
Sakai Y, Hirano T, Tachikawa M. (2019) Molecular Dynamics Simulations of Condensin-Mediated Mitotic Chromosome Assembly. Methods in Molecular Biology (Clifton, N.J.). 2004: 319-334
Hara K, Kinoshita K, Migita T, et al. (2019) Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex. Embo Reports
Shintomi K, Hirano T. (2018) Reconstitution of Mitotic Chromatids In Vitro. Current Protocols in Cell Biology. 79: e48
Sakai Y, Mochizuki A, Kinoshita K, et al. (2018) Modeling the functions of condensin in chromosome shaping and segregation. Plos Computational Biology. 14: e1006152
Takagi M, Ono T, Natsume T, et al. (2018) Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms. Journal of Cell Science
Shintomi K, Hirano T. (2017) Mitotic Chromosome Assembly In Vitro: Functional Cross Talk between Nucleosomes and Condensins. Cold Spring Harbor Symposia On Quantitative Biology. 82: 157-164
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