Tatsuya Hirano, Ph. D.

1995-2007 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
 2007- RIKEN 
Cell biology; Biochemistry; Chromosomes; Condensins
"Tatsuya Hirano"
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Yoshida MM, Kinoshita K, Shintomi K, et al. (2023) Regulation of condensin II by self-suppression and release mechanisms. Molecular Biology of the Cell. 35: ar21
Yamamoto T, Kinoshita K, Hirano T. (2023) Elasticity control of entangled chromosomes: Crosstalk between condensin complexes and nucleosomes. Biophysical Journal
Sun M, Amiri H, Tong AB, et al. (2023) Monitoring the compaction of single DNA molecules in egg extract in real time. Proceedings of the National Academy of Sciences of the United States of America. 120: e2221309120
Tane S, Shintomi K, Kinoshita K, et al. (2022) Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit. Elife. 11
Yoshida MM, Kinoshita K, Aizawa Y, et al. (2022) Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays. Elife. 11
Yamazaki H, Takagi M, Kosako H, et al. (2022) Cell cycle-specific phase separation regulated by protein charge blockiness. Nature Cell Biology. 24: 625-632
Kinoshita K, Tsubota Y, Tane S, et al. (2022) A loop extrusion-independent mechanism contributes to condensin I-mediated chromosome shaping. The Journal of Cell Biology. 221
Shintomi K, Hirano T. (2021) Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly. Nature Communications. 12: 2917
Sakai Y, Hirano T, Tachikawa M. (2019) Molecular Dynamics Simulations of Condensin-Mediated Mitotic Chromosome Assembly. Methods in Molecular Biology (Clifton, N.J.). 2004: 319-334
Hara K, Kinoshita K, Migita T, et al. (2019) Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex. Embo Reports
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