John Cleary
Affiliations: | 2000-2010 | Molecular Genetics | University of Toronto, Toronto, ON, Canada |
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"John Cleary"
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Shorrock HK, Lennon CD, Aliyeva A, et al. (2023) Widespread alternative splicing dysregulation occurs presymptomatically in CAG expansion spinocerebellar ataxias. Brain : a Journal of Neurology |
Mishra SK, Hicks SM, Frias JA, et al. (2023) Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy. Biorxiv : the Preprint Server For Biology |
Reddy K, Cleary JD, Berglund JA. (2020) Drug Screen Tugs at Common Thread for Repeat Disorders. Trends in Pharmacological Sciences |
Reddy K, Jenquin JR, McConnell OL, et al. (2019) A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels. Proceedings of the National Academy of Sciences of the United States of America |
Reddy K, Jenquin JR, Cleary JD, et al. (2019) Mitigating RNA Toxicity in Myotonic Dystrophy using Small Molecules. International Journal of Molecular Sciences. 20 |
Pinto BS, Saxena T, Oliveira R, et al. (2017) Impeding Transcription of Expanded Microsatellite Repeats by Deactivated Cas9. Molecular Cell |
Cleary JD, Ranum LP. (2014) Repeat associated non-ATG (RAN) translation: new starts in microsatellite expansion disorders. Current Opinion in Genetics & Development. 26: 6-15 |
Cleary JD, Tomé S, López Castel A, et al. (2010) Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus. Nature Structural & Molecular Biology. 17: 1079-87 |
López Castel A, Cleary JD, Pearson CE. (2010) Repeat instability as the basis for human diseases and as a potential target for therapy. Nature Reviews. Molecular Cell Biology. 11: 165-70 |
Libby RT, Hagerman KA, Pineda VV, et al. (2008) CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination. Plos Genetics. 4: e1000257 |