G Greg Wang

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
stem cells, cancer, epigenetics
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"G Greg Wang"

Parents

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Mark Kamps grad student (Neurotree)
C. David Allis post-doc Rockefeller (PombeTree)
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Publications

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Lu R, Wang P, Parton T, et al. (2016) Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development. Cancer Cell
Zhang ZM, Rothbart SB, Allison DF, et al. (2015) An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Reports. 12: 1400-6
Xu B, On DM, Ma A, et al. (2015) Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood. 125: 346-57
Gough SM, Lee F, Yang F, et al. (2014) NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function. Cancer Discovery. 4: 564-77
Konze KD, Ma A, Li F, et al. (2013) An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. Acs Chemical Biology. 8: 1324-34
Cai L, Rothbart SB, Lu R, et al. (2013) An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Molecular Cell. 49: 571-82
Kumar GS, Chang W, Xie T, et al. (2012) Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex. Journal of Molecular Biology. 422: 519-31
Chi P, Allis CD, Wang GG. (2010) Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nature Reviews. Cancer. 10: 457-69
Milne TA, Kim J, Wang GG, et al. (2010) Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Molecular Cell. 38: 853-63
Wang Z, Song J, Milne TA, et al. (2010) Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell. 141: 1183-94
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