Gerald Ralph Smith

Affiliations: 
1975-1982 Biology University of Oregon, Eugene, OR, United States 
 1982- Fred Hutchinson Cancer Research Center, Seattle, WA, United States 
 1983- Genome Sciences and Pathology University of Washington School of Medicine, Seattle, WA, United States 
Area:
Recombination and DNA Break Repair
Website:
https://sharedresources.fredhutch.org/profile/smith-gerald
Google:
"Gerald Ralph Smith"

Parents

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Boris Magasanik grad student 1970 MIT
 (Genetic regulation of histidine degradation in enteric bacteria: structure and function of the operons.)
Bruce Nathan Ames post-doc 1970-1972 UC Berkeley (Chemistry Tree)
Harvey Eisen post-doc 1972-1975 Université de Genève (Neurotree)
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Publications

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Hyppa RW, Cho JD, Nambiar M, et al. (2021) Redirecting meiotic DNA break hotspot determinant proteins alters localized spatial control of DNA break formation and repair. Nucleic Acids Research
Amundsen SK, Taylor AF, Smith GR. (2020) Chi hotspot control of RecBCD helicase-nuclease by long-range intramolecular signaling. Scientific Reports. 10: 19415
Karabulut AC, Cirz RT, Taylor AF, et al. (2020) Small-molecule sensitization of RecBCD helicase-nuclease to a Chi hotspot-activated state. Nucleic Acids Research
Nambiar M, Chuang YC, Smith GR. (2019) Distributing meiotic crossovers for optimal fertility and evolution. Dna Repair. 102648
Amundsen SK, Smith GR. (2018) The RecB helicase-nuclease tether mediates Chi hotspot control of RecBCD enzyme. Nucleic Acids Research
Fowler KR, Hyppa RW, Cromie GA, et al. (2018) Physical basis for long-distance communication along meiotic chromosomes. Proceedings of the National Academy of Sciences of the United States of America
Nambiar M, Smith GR. (2018) Pericentromere-Specific Cohesin Complex Prevents Meiotic Pericentric DNA Double-Strand Breaks and Lethal Crossovers. Molecular Cell. 71: 540-553.e4
Nuckolls NL, Bravo Núñez MA, Eickbush MT, et al. (2017) genes are prolific dual poison-antidote meiotic drivers. Elife. 6
Ma L, Fowler KR, Martín-Castellanos C, et al. (2017) Functional organization of protein determinants of meiotic DNA break hotspots. Scientific Reports. 7: 1393
Hyppa RW, Fowler KR, Smith GR. (2017) Quantitative Genome-Wide Measurements of Meiotic DNA Double-Strand Breaks and Protein Binding in S. pombe. Methods in Molecular Biology (Clifton, N.J.). 1471: 25-49
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