Gerald Ralph Smith
Affiliations: | 1975-1982 | Biology | University of Oregon, Eugene, OR, United States |
| 1982- | Fred Hutchinson Cancer Research Center, Seattle, WA, United States | ||
| 1983- | Genome Sciences and Pathology | University of Washington School of Medicine, Seattle, WA, United States |
Area:
Recombination and DNA Break RepairWebsite:
https://sharedresources.fredhutch.org/profile/smith-geraldGoogle:
"Gerald Ralph Smith"Parents
Sign in to add mentor| Boris Magasanik | grad student | 1970 | MIT | |
| (Genetic regulation of histidine degradation in enteric bacteria: structure and function of the operons.) | ||||
| Bruce Nathan Ames | post-doc | 1970-1972 | UC Berkeley (Chemistry Tree) | |
| Harvey Eisen | post-doc | 1972-1975 | Université de Genève (Neurotree) | |
Children
Sign in to add trainee| Keith C. Cheng | grad student | 1987 | Fred Hutchinson Cancer Research Center/UW (Neurotree) |
| Alfred S. Ponticelli | grad student | 1988 | University of Washington (Chemistry Tree) |
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Publications
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| Wang MF, Li MY, Yang YC, et al. (2025) Mug20-Rec25-Rec27 binds DNA and enhances meiotic DNA break formation via phase-separated condensates. Nucleic Acids Research. 53 |
| Zheng C, Furukawa C, Liu J, et al. (2024) Debunking the dogma that RecBCD nuclease destroys phage. Genetics |
| Amundsen SK, Smith GR. (2024) Chi hotspot Control of RecBCD Helicase-nuclease: Enzymatic Tests Support the Intramolecular Signal-transduction Model. Journal of Molecular Biology. 436: 168482 |
| Amundsen SK, Smith GR. (2023) RecBCD enzyme: mechanistic insights from mutants of a complex helicase-nuclease. Microbiology and Molecular Biology Reviews : Mmbr. e0004123 |
| Amundsen SK, Richardson A, Ha K, et al. (2022) A flexible RecC surface loop required for Chi hotspot control of RecBCD enzyme. Genetics |
| Hyppa RW, Cho JD, Nambiar M, et al. (2021) Redirecting meiotic DNA break hotspot determinant proteins alters localized spatial control of DNA break formation and repair. Nucleic Acids Research |
| Amundsen SK, Taylor AF, Smith GR. (2020) Chi hotspot control of RecBCD helicase-nuclease by long-range intramolecular signaling. Scientific Reports. 10: 19415 |
| Karabulut AC, Cirz RT, Taylor AF, et al. (2020) Small-molecule sensitization of RecBCD helicase-nuclease to a Chi hotspot-activated state. Nucleic Acids Research |
| Nambiar M, Chuang YC, Smith GR. (2019) Distributing meiotic crossovers for optimal fertility and evolution. Dna Repair. 102648 |
| Amundsen SK, Smith GR. (2018) The RecB helicase-nuclease tether mediates Chi hotspot control of RecBCD enzyme. Nucleic Acids Research |